Mouse Gene Pax5 (ENSMUST00000014174.13) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus paired box 5 (Pax5), mRNA. (from RefSeq NM_008782)
Gencode Transcript: ENSMUST00000014174.13
Gencode Gene: ENSMUSG00000014030.15
Transcript (Including UTRs)
   Position: mm10 chr4:44,524,757-44,710,487 Size: 185,731 Total Exon Count: 10 Strand: -
Coding Region
   Position: mm10 chr4:44,531,506-44,710,408 Size: 178,903 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:44,524,757-44,710,487)mRNA (may differ from genome)Protein (391 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
MGIPubMedReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: PAX5_MOUSE
DESCRIPTION: RecName: Full=Paired box protein Pax-5; AltName: Full=B-cell-specific transcription factor; Short=BSAP;
FUNCTION: May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.
SUBUNIT: Interacts with ETS1, altering its DNA-binding properties (By similarity). Interacts with DAXX and TLE4. Binds DNA as a monomer.
INTERACTION: Q9UER7:DAXX (xeno); NbExp=4; IntAct=EBI-296260, EBI-77321;
SUBCELLULAR LOCATION: Nucleus.
DEVELOPMENTAL STAGE: Expressed at early B-cell differentiation, in the developing CNS and in adult testis.
PTM: O-glycosylated (Probable).
SIMILARITY: Contains 1 paired domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  mRNA Secondary Structure of 3' and 5' UTRs
  Press "+" in the title bar above to open this section.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009057 - Homeodomain-like
IPR001523 - Paired_dom
IPR022130 - Pax2_C
IPR011991 - WHTH_trsnscrt_rep_DNA-bd

Pfam Domains:
PF00292 - 'Paired box' domain
PF12403 - Paired-box protein 2 C terminal

SCOP Domains:
46689 - Homeodomain-like
46785 - "Winged helix" DNA-binding domain

ModBase Predicted Comparative 3D Structure on Q02650
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007275 multicellular organism development
GO:0007283 spermatogenesis
GO:0007399 nervous system development
GO:0007568 aging
GO:0009887 animal organ morphogenesis
GO:0021670 lateral ventricle development
GO:0021987 cerebral cortex development
GO:0030154 cell differentiation
GO:0030534 adult behavior
GO:0035914 skeletal muscle cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0051573 negative regulation of histone H3-K9 methylation
GO:0071542 dopaminergic neuron differentiation

Cellular Component:
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005829 cytosol
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  M97013 - Mouse B-cell specific transcription factor (Pax-5) mRNA, complete cds.
BC156134 - Synthetic construct Mus musculus clone IMAGE:100062425, MGC:190876 paired box gene 5 (Pax5) mRNA, encodes complete protein.
BC157081 - Synthetic construct Mus musculus clone IMAGE:100063396, MGC:191076 paired box gene 5 (Pax5) mRNA, encodes complete protein.
JX065130 - Mus musculus Pax5 variant 1 mRNA, partial cds.
JX065132 - Mus musculus Pax5-like (Pax5) mRNA, complete sequence.
AK040987 - Mus musculus adult male aorta and vein cDNA, RIKEN full-length enriched library, clone:A530055P18 product:unclassifiable, full insert sequence.
AK144818 - Mus musculus lung RCB-0558 LLC cDNA, RIKEN full-length enriched library, clone:G730037P22 product:unclassifiable, full insert sequence.
JX065131 - Mus musculus Pax5 variant 2 mRNA, partial cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q02650 (Reactome details) participates in the following event(s):

R-MMU-8938951 RUNX1 binds PAX5 (BSAP)
R-MMU-8939245 RUNX1 regulates transcription of genes involved in BCR signaling
R-MMU-8878171 Transcriptional regulation by RUNX1
R-MMU-212436 Generic Transcription Pathway
R-MMU-73857 RNA Polymerase II Transcription
R-MMU-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: NM_008782, Pax-5, PAX5_MOUSE, Q02650, uc008srx.1, uc008srx.2
UCSC ID: uc008srx.2
RefSeq Accession: NM_008782
Protein: Q02650 (aka PAX5_MOUSE)
CCDS: CCDS18125.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.