Mouse Gene Otx2 (ENSMUST00000227404.1) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Nucleus (By similarity). (from UniProt Q8VD35) RefSeq Summary (NM_001286482): This gene encodes a protein that belongs to the homeobox family of transcription factors. The encoded protein plays a role in the development and patterning of the head. This protein regulates development of the choroid plexuses in the brain affecting composition of cerebrospinal fluid in the developing brain and is thought to function in the development of sense organs in the embryo. In humans, mutations in this gene are associated with pituitary hormone deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2013]. Gencode Transcript: ENSMUST00000227404.1 Gencode Gene: ENSMUSG00000021848.16 Transcript (Including UTRs) Position: mm10 chr14:48,657,851-48,673,819 Size: 15,969 Total Exon Count: 5 Strand: - Coding Region Position: mm10 chr14:48,658,706-48,662,540 Size: 3,835 Coding Exon Count: 3
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8VD35
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.