Mouse Gene Alx1 (ENSMUST00000218282.1) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Transcriptional activator that acts at a palindromic recognition sequence to enhance the activity of the SV40 and TK promoters. May play a role in chondrocyte differentiation and may also influence cervix development (By similarity). (from UniProt Q8C8B0) Gencode Transcript: ENSMUST00000218282.1 Gencode Gene: ENSMUSG00000036602.14 Transcript (Including UTRs) Position: mm10 chr10:103,008,864-103,030,215 Size: 21,352 Total Exon Count: 8 Strand: - Coding Region Position: mm10 chr10:103,009,188-103,028,606 Size: 19,419 Coding Exon Count: 4
ID:ALX1_MOUSE DESCRIPTION: RecName: Full=ALX homeobox protein 1; AltName: Full=Cartilage homeoprotein 1; Short=CART-1; FUNCTION: Transcriptional activator that acts at a palindromic recognition sequence to enhance the activity of the SV40 and TK promoters. May play a role in chondrocyte differentiation and may also influence cervix development (By similarity). SUBUNIT: Interacts (via homeobox domain) with EP300. SUBCELLULAR LOCATION: Nucleus. PTM: Acetylated at Lys-131 by EP300, leading to increased interaction with EP300 and enhances transcriptional activation activity. SIMILARITY: Belongs to the paired homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain.
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Protein Domain and Structure Information
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
