Mouse Gene Alx1 (ENSMUST00000218282.1) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Transcriptional activator that acts at a palindromic recognition sequence to enhance the activity of the SV40 and TK promoters. May play a role in chondrocyte differentiation and may also influence cervix development (By similarity). (from UniProt Q8C8B0)
Gencode Transcript: ENSMUST00000218282.1
Gencode Gene: ENSMUSG00000036602.14
Transcript (Including UTRs)
   Position: mm10 chr10:103,008,864-103,030,215 Size: 21,352 Total Exon Count: 8 Strand: -
Coding Region
   Position: mm10 chr10:103,009,188-103,028,606 Size: 19,419 Coding Exon Count: 4 

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Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:103,008,864-103,030,215)mRNA (may differ from genome)Protein (326 aa)
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-  Comments and Description Text from UniProtKB
  ID: ALX1_MOUSE
DESCRIPTION: RecName: Full=ALX homeobox protein 1; AltName: Full=Cartilage homeoprotein 1; Short=CART-1;
FUNCTION: Transcriptional activator that acts at a palindromic recognition sequence to enhance the activity of the SV40 and TK promoters. May play a role in chondrocyte differentiation and may also influence cervix development (By similarity).
SUBUNIT: Interacts (via homeobox domain) with EP300.
SUBCELLULAR LOCATION: Nucleus.
PTM: Acetylated at Lys-131 by EP300, leading to increased interaction with EP300 and enhances transcriptional activation activity.
SIMILARITY: Belongs to the paired homeobox family.
SIMILARITY: Contains 1 homeobox DNA-binding domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  mRNA Secondary Structure of 3' and 5' UTRs
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+  Protein Domain and Structure Information
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
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Gene Details     
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+  Gene Ontology (GO) Annotations with Structured Vocabulary
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-  Descriptions from all associated GenBank mRNAs
  AK047846 - Mus musculus 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130005I02 product:cartilage homeo protein 1, full insert sequence.
BC052200 - Mus musculus ALX homeobox 1, mRNA (cDNA clone MGC:59626 IMAGE:6513129), complete cds.
AK086731 - Mus musculus 15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930048F05 product:cartilage homeo protein 1, full insert sequence.
AK032803 - Mus musculus 12 days embryo male wolffian duct includes surrounding region cDNA, RIKEN full-length enriched library, clone:6720455D18 product:unclassifiable, full insert sequence.
AK081538 - Mus musculus 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130035K18 product:CARTILAGE HOMEOPROTEIN 1 (CART-1) homolog [Homo sapiens], full insert sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: AK047846, ALX1_MOUSE, Cart1, Q8C370, Q8C8B0, uc287upk.1
UCSC ID: uc287upk.1
RefSeq Accession: NM_172553
Protein: Q8C8B0 (aka ALX1_MOUSE)
CCDS: CCDS24155.1

+  Gene Model Information
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.