ID:DRGX_MOUSE DESCRIPTION: RecName: Full=Dorsal root ganglia homeobox protein; AltName: Full=Dorsal root ganglion 11; AltName: Full=Homeobox protein DRG11; AltName: Full=Paired-related homeobox protein-like 1; FUNCTION: Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain. SUBUNIT: Interacts with RGMB. SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Expressed in the dorsal horn of the spinal cord and dorsal root ganglia. Isoform 1 is higher expressed than isoform 2 both in the dorsal root ganglia and in the spinal cord. Isoform 2 is exclusively localized in neurons primarily involved in the processing of the pain somatosensory modality. DEVELOPMENTAL STAGE: First detected at E12.5 in newly generated neurons adjacent to the ventricular zone of the dorsal spinal cord. Later expressed in lateral region of the dorsal spinal cord and dorsal root ganglia at E13.5 with increased levels at E15.5. DISRUPTION PHENOTYPE: Defects in the projection pattern of nociceptive sensory neurons to the dorsal horn of the developing spinal cord leading to reduced sensitivity to painful stimuli. They die within 3 weeks of birth. Mice lacking Drgx exhibit reduced expression of Rgmb in dorsal root ganglion sensory neurons. SIMILARITY: Belongs to the paired homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8BYH0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0001764 neuron migration GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0007275 multicellular organism development GO:0007399 nervous system development GO:0007409 axonogenesis GO:0007411 axon guidance GO:0009593 detection of chemical stimulus GO:0016048 detection of temperature stimulus GO:0021516 dorsal spinal cord development GO:0021559 trigeminal nerve development GO:0030182 neuron differentiation GO:0050954 sensory perception of mechanical stimulus
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