Mouse Gene Pitx2 (ENSMUST00000174661.8) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus paired-like homeodomain transcription factor 2 (Pitx2), transcript variant 2, mRNA. (from RefSeq NM_011098)
Gencode Transcript: ENSMUST00000174661.8
Gencode Gene: ENSMUSG00000028023.16
Transcript (Including UTRs)
   Position: mm10 chr3:129,199,878-129,219,590 Size: 19,713 Total Exon Count: 5 Strand: +
Coding Region
   Position: mm10 chr3:129,203,947-129,218,897 Size: 14,951 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:129,199,878-129,219,590)mRNA (may differ from genome)Protein (317 aa)
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-  Comments and Description Text from UniProtKB
  ID: PITX2_MOUSE
DESCRIPTION: RecName: Full=Pituitary homeobox 2; AltName: Full=ALL1-responsive protein ARP1; AltName: Full=BRX1 homeoprotein; AltName: Full=Homeobox protein PITX2; AltName: Full=Orthodenticle-like homeobox 2; AltName: Full=Paired-like homeodomain transcription factor 2; AltName: Full=Paired-like homeodomain transcription factor Munc 30; AltName: Full=Solurshin;
FUNCTION: Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform Ptx2c is involved in left-right asymmetry the developing embryo.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: In day-11 embryos, expressed in the periocular mesenchyme, maxillary and mandibular epithelia, umbilicus, Rathke pouch, vitelline vessels and limb mesenchyme. In adult tissues, expressed in pituitary gland, brain, kidney, eye, lung, testis and tongue.
DEVELOPMENTAL STAGE: Expressed in the embryonic heart. Expressed in the left lateral plate mesoderm and symmetrically in the head mesoderm at 8.5 dpc. Isoform Ptx2c is expressed in the ventral outflow tract region (OFT), right ventricle (RV) and in the left atrium of the heart.
PTM: Phosphorylation at Thr-90 impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1.
DISRUPTION PHENOTYPE: Mice embryos lacking isoform Ptx2c show left-right patterning defects and severe developmental abnormalities.
SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
SIMILARITY: Contains 1 homeobox DNA-binding domain.
SEQUENCE CAUTION: Sequence=AAF44618.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  mRNA Secondary Structure of 3' and 5' UTRs
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+  Protein Domain and Structure Information
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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 RGD    
 Protein Sequence    
 Alignment    

+  Gene Ontology (GO) Annotations with Structured Vocabulary
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-  Descriptions from all associated GenBank mRNAs
  LF202534 - JP 2014500723-A/10037: Polycomb-Associated Non-Coding RNAs.
LF194204 - JP 2014500723-A/1707: Polycomb-Associated Non-Coding RNAs.
AB006321 - Mus musculus mRNA for Brx1b homeoprotein, complete cds.
U80011 - Mus musculus pituitary homeobox 2 isoform a (Pitx2) mRNA, complete cds.
U80036 - Mus musculus orthodenticle-like homeobox 2 (Otlx2) mRNA, complete cds.
AF048723 - Mus musculus ALL1 responsive protein ARP1a (Arp1) mRNA, complete cds.
U80010 - Mus musculus pituitary homeobox 2 isoform b (Pitx2) mRNA, complete cds.
AM940438 - Mus musculus mRNA for paired-like homeodomain transcription factor 2, isoform 2b2 (Pitx2 gene), transcript variant 4, strain CD-1.
LF202536 - JP 2014500723-A/10039: Polycomb-Associated Non-Coding RNAs.
AK034846 - Mus musculus 12 days embryo embryonic body between diaphragm region and neck cDNA, RIKEN full-length enriched library, clone:9430046L11 product:paired-like homeodomain transcription factor 2, full insert sequence.
AF048724 - Mus musculus ALL1 responsive protein ARP1c (Arp1) mRNA, complete cds.
BC075660 - Mus musculus paired-like homeodomain transcription factor 2, mRNA (cDNA clone MGC:96389 IMAGE:30606653), complete cds.
AK035083 - Mus musculus 12 days embryo embryonic body between diaphragm region and neck cDNA, RIKEN full-length enriched library, clone:9430085M16 product:paired-like homeodomain transcription factor 2, full insert sequence.
AB006320 - Mus musculus Brx1a mRNA for homeoprotein, complete cds.
AF201091 - Mus musculus paired-like homeodomain transcription factor Munc 30 mRNA, partial cds.
AM940439 - Mus musculus mRNA for Pitx2cbeta (Pitx2 gene), transcript variant 3, strain CD-1.
U70132 - Mus musculus bicoid-related homeodomain protein solurshin (Rgs) mRNA, partial cds.
LF269564 - JP 2014500723-A/77067: Polycomb-Associated Non-Coding RNAs.
MA438111 - JP 2018138019-A/10037: Polycomb-Associated Non-Coding RNAs.
MA429781 - JP 2018138019-A/1707: Polycomb-Associated Non-Coding RNAs.
MA438113 - JP 2018138019-A/10039: Polycomb-Associated Non-Coding RNAs.
MA505141 - JP 2018138019-A/77067: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04350 - TGF-beta signaling pathway

BioCarta from NCI Cancer Genome Anatomy Project
m_pitx2Pathway - Multi-step Regulation of Transcription by Pitx2

-  Other Names for This Gene
  Alternate Gene Symbols: Arp1, Brx1, NM_011098, O08646, O70336, Otlx2, P97474, P97933, PITX2_MOUSE, Ptx2, Q9JLA0, Q9QXB8, Q9R1V9, Q9Z141, Rgs, uc008rhu.1, uc008rhu.2, uc008rhu.3
UCSC ID: uc008rhu.3
RefSeq Accession: NM_011098
Protein: P97474 (aka PITX2_MOUSE)
CCDS: CCDS17830.1, CCDS71316.1

+  Gene Model Information
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-  Methods, Credits, and Use Restrictions
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