Mouse Gene Uncx (ENSMUST00000172997.2) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus UNC homeobox (Uncx), mRNA. (from RefSeq NM_013702)
Gencode Transcript: ENSMUST00000172997.2
Gencode Gene: ENSMUSG00000029546.12
Transcript (Including UTRs)
   Position: mm10 chr5:139,543,494-139,548,179 Size: 4,686 Total Exon Count: 3 Strand: +
Coding Region
   Position: mm10 chr5:139,543,994-139,547,774 Size: 3,781 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:139,543,494-139,548,179)mRNA (may differ from genome)Protein (530 aa)
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-  Comments and Description Text from UniProtKB
  ID: UNC4_MOUSE
DESCRIPTION: RecName: Full=Homeobox protein unc-4 homolog; AltName: Full=Homeobox protein Uncx4.1;
FUNCTION: Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions.
SUBCELLULAR LOCATION: Nucleus (By similarity).
TISSUE SPECIFICITY: Expressed in the paraxial mesoderm, in the developing kidney and central nervous system. In the somite, it is restricted to the caudal half of the newly formed somite and sclerotome. In the central nervous system, it is detected in the developing spinal cord, hindbrain, mesencephalon and telencephalon. Expressed in adult and embryonic magnocellular neurons of the hypothalamo-neurohypophysial system.
DISRUPTION PHENOTYPE: Mice die perinatally and exhibit severe malformations of the axial skeleton. Pedicles of the neural arches and proximal ribs are not formed. In addition, dorsal root ganglia are disorganized. In the hypothalamo-neurohypophysial system, neurons are viable and able to express neuropeptides; however, the connectivity of magnocellular neurons with posterior pituitary elements is compromised.
MISCELLANEOUS: Marker of antero-posterior subdivisions of the somite.
SIMILARITY: Belongs to the paired homeobox family. Unc-4 subfamily.
SIMILARITY: Contains 1 homeobox DNA-binding domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  mRNA Secondary Structure of 3' and 5' UTRs
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+  Protein Domain and Structure Information
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details     
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Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

+  Gene Ontology (GO) Annotations with Structured Vocabulary
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-  Descriptions from all associated GenBank mRNAs
  S83543 - Cer-1=cerebellar-expressed gene/granule neuron differentiation-associated gene [mice, cerebellum, granule neurons, mRNA Partial, 622 nt].
AK082472 - Mus musculus 0 day neonate cerebellum cDNA, RIKEN full-length enriched library, clone:C230053I05 product:Unc4.1 homeobox (C. elegans), full insert sequence.
AF247550 - Mus musculus UNC4 protein mRNA, complete cds.
Z96107 - Mus musculus mRNA for Uncx4.1.
BC051973 - Mus musculus UNC homeobox, mRNA (cDNA clone MGC:62254 IMAGE:5718115), complete cds.
AJ001116 - Mus musculus mRNA for Uncx4.1 protein.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_013702, O08934, P70457, Q78DU3, uc009agv.1, uc009agv.2, uc009agv.3, UNC4_MOUSE, Uncx4.1
UCSC ID: uc009agv.3
RefSeq Accession: NM_013702
Protein: O08934 (aka UNC4_MOUSE)
CCDS: CCDS19813.1

+  Gene Model Information
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-  Methods, Credits, and Use Restrictions
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