Mouse Gene Prop1 (ENSMUST00000051159.2) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus paired like homeodomain factor 1 (Prop1), mRNA. (from RefSeq NM_008936)
Gencode Transcript: ENSMUST00000051159.2
Gencode Gene: ENSMUSG00000044542.3
Transcript (Including UTRs)
   Position: mm10 chr11:50,950,806-50,953,765 Size: 2,960 Total Exon Count: 3 Strand: -
Coding Region
   Position: mm10 chr11:50,950,906-50,953,404 Size: 2,499 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:50,950,806-50,953,765)mRNA (may differ from genome)Protein (223 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
MGIPubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Homeobox protein prophet of Pit-1; Short=PROP-1; AltName: Full=Pituitary-specific homeodomain factor;
FUNCTION: Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.
INTERACTION: Q02248:Ctnnb1; NbExp=2; IntAct=EBI-937831, EBI-397872;
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Belongs to the paired homeobox family.
SIMILARITY: Contains 1 homeobox DNA-binding domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -50.20361-0.139 Picture PostScript Text
3' UTR -29.70100-0.297 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017970 - Homeobox_CS
IPR001356 - Homeodomain
IPR009057 - Homeodomain-like

Pfam Domains:
PF00046 - Homeobox domain

SCOP Domains:
46689 - Homeodomain-like

ModBase Predicted Comparative 3D Structure on P97458
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008022 protein C-terminus binding
GO:0043565 sequence-specific DNA binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001568 blood vessel development
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0009887 animal organ morphogenesis
GO:0009953 dorsal/ventral pattern formation
GO:0016477 cell migration
GO:0021979 hypothalamus cell differentiation
GO:0021984 adenohypophysis development
GO:0043066 negative regulation of apoptotic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048732 gland development
GO:0048850 hypophysis morphogenesis
GO:0060070 canonical Wnt signaling pathway
GO:0060126 somatotropin secreting cell differentiation

Cellular Component:
GO:0005634 nucleus
GO:0005667 transcription factor complex

-  Descriptions from all associated GenBank mRNAs
  U77946 - Mus musculus pituitary specific homeodomain factor (Prop-1) mRNA, complete cds.
BC160334 - Synthetic construct Mus musculus clone IMAGE:100064078, MGC:193449 paired like homeodomain factor 1 (Prop1) mRNA, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_008936, P97458, Prop-1, PROP1_MOUSE, Q5NCG9, uc007itg.1, uc007itg.2
UCSC ID: uc007itg.2
RefSeq Accession: NM_008936
Protein: P97458 (aka PROP1_MOUSE or PRH1_MOUSE)
CCDS: CCDS24643.1

+  Gene Model Information
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.