Mouse Gene Prop1 (ENSMUST00000051159.2) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus paired like homeodomain factor 1 (Prop1), mRNA. (from RefSeq NM_008936)
Gencode Transcript: ENSMUST00000051159.2
Gencode Gene: ENSMUSG00000044542.3
Transcript (Including UTRs)
   Position: mm10 chr11:50,950,806-50,953,765 Size: 2,960 Total Exon Count: 3 Strand: -
Coding Region
   Position: mm10 chr11:50,950,906-50,953,404 Size: 2,499 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:50,950,806-50,953,765)mRNA (may differ from genome)Protein (223 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
MGIPubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: PROP1_MOUSE
DESCRIPTION: RecName: Full=Homeobox protein prophet of Pit-1; Short=PROP-1; AltName: Full=Pituitary-specific homeodomain factor;
FUNCTION: Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.
INTERACTION: Q02248:Ctnnb1; NbExp=2; IntAct=EBI-937831, EBI-397872;
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Belongs to the paired homeobox family.
SIMILARITY: Contains 1 homeobox DNA-binding domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -50.20361-0.139 Picture PostScript Text
3' UTR -29.70100-0.297 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017970 - Homeobox_CS
IPR001356 - Homeodomain
IPR009057 - Homeodomain-like

Pfam Domains:
PF00046 - Homeobox domain

SCOP Domains:
46689 - Homeodomain-like

ModBase Predicted Comparative 3D Structure on P97458
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008022 protein C-terminus binding
GO:0043565 sequence-specific DNA binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001568 blood vessel development
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0009887 animal organ morphogenesis
GO:0009953 dorsal/ventral pattern formation
GO:0016477 cell migration
GO:0021979 hypothalamus cell differentiation
GO:0021984 adenohypophysis development
GO:0043066 negative regulation of apoptotic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048732 gland development
GO:0048850 hypophysis morphogenesis
GO:0060070 canonical Wnt signaling pathway
GO:0060126 somatotropin secreting cell differentiation

Cellular Component:
GO:0005634 nucleus
GO:0005667 transcription factor complex


-  Descriptions from all associated GenBank mRNAs
  U77946 - Mus musculus pituitary specific homeodomain factor (Prop-1) mRNA, complete cds.
BC160334 - Synthetic construct Mus musculus clone IMAGE:100064078, MGC:193449 paired like homeodomain factor 1 (Prop1) mRNA, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_008936, P97458, Prop-1, PROP1_MOUSE, Q5NCG9, uc007itg.1, uc007itg.2
UCSC ID: uc007itg.2
RefSeq Accession: NM_008936
Protein: P97458 (aka PROP1_MOUSE or PRH1_MOUSE)
CCDS: CCDS24643.1

+  Gene Model Information
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.