Mouse Gene Arx (ENSMUST00000046565.12) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus aristaless related homeobox (Arx), transcript variant 1, mRNA. (from RefSeq NM_007492) RefSeq Summary (NM_007492): This gene encodes a transcription factor that plays an important role in the development of forebrain. Male mice lacking this gene have smaller brains, olfactory bulbs and testes, and die within half a day after birth. Mice lacking this gene specifically in ganglionic eminence-derived neurons, including cortical interneurons, develop seizures. Mutations in this gene have been demonstrated to cause mouse phenotypes resembling human X-linked lissencephaly and cognitive disability with epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. Gencode Transcript: ENSMUST00000046565.12 Gencode Gene: ENSMUSG00000035277.15 Transcript (Including UTRs) Position: mm10 chrX:93,286,496-93,298,357 Size: 11,862 Total Exon Count: 5 Strand: + Coding Region Position: mm10 chrX:93,286,728-93,297,403 Size: 10,676 Coding Exon Count: 5
ID:ARX_MOUSE DESCRIPTION: RecName: Full=Homeobox protein ARX; AltName: Full=Aristaless-related homeobox; FUNCTION: Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily. SIMILARITY: Contains 1 homeobox DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O35085
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.