ID:VSX1_MOUSE DESCRIPTION: RecName: Full=Visual system homeobox 1; AltName: Full=Homeodomain protein RINX; AltName: Full=Retinal inner nuclear layer homeobox protein; AltName: Full=Transcription factor VSX1; FUNCTION: Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster. May regulate the activity of the LCR and the cone opsin genes at earlier stages of development (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: In the adult, expressed exclusively in the cells of the neural retina with expression restricted to postnatal cone bipolar interneurons. DEVELOPMENTAL STAGE: Expressed at P5, solely within the inner nuclear layer (INL) of the central neuroretina. By days P6 and P7, expression expands peripherally during neurogenesis. By P12, expression is restricted to the outer margin of the INL and reaches the outer periphery of the neuroretina. SIMILARITY: Belongs to the paired homeobox family. SIMILARITY: Contains 1 CVC domain. SIMILARITY: Contains 1 homeobox DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q91V10
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003677 DNA binding GO:0003682 chromatin binding GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0007275 multicellular organism development GO:0007601 visual perception GO:0042551 neuron maturation GO:0048666 neuron development GO:0050896 response to stimulus GO:0060040 retinal bipolar neuron differentiation
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