Mouse Gene Alx4 (ENSMUST00000042078.9) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus aristaless-like homeobox 4 (Alx4), mRNA. (from RefSeq NM_007442)
Gencode Transcript: ENSMUST00000042078.9
Gencode Gene: ENSMUSG00000040310.12
Transcript (Including UTRs)
   Position: mm10 chr2:93,642,384-93,681,339 Size: 38,956 Total Exon Count: 4 Strand: +
Coding Region
   Position: mm10 chr2:93,642,659-93,677,561 Size: 34,903 Coding Exon Count: 4 

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Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:93,642,384-93,681,339)mRNA (may differ from genome)Protein (399 aa)
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-  Comments and Description Text from UniProtKB
  ID: ALX4_MOUSE
DESCRIPTION: RecName: Full=Homeobox protein aristaless-like 4; AltName: Full=ALX-4;
FUNCTION: Transcription factor involved in skull and limb development.
SUBUNIT: Binds DNA.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Expressed in osteoblasts. Not expressed in brain, heart, intestine, kidney, liver, muscle, spleen and testis.
DEVELOPMENTAL STAGE: Expressed from E8.25 and confined to mesenchymal cells throughout the embryo development. Expression is seen at several sites including craniofacial region, first branchial arch and anterior aspect of the limb bud.
DISEASE: Note=Defects in Alx4 are the cause of Strong luxoid (lst) phenotype. At heterozygosity lst is characterized by preaxial abnormalities of the hindfeet and, very rarely, of the forefeet. Homozygotes show preaxial polydactyly of all four limbs, reductions and duplications of the radius, absence of the tibia, craniofacial defects, reduction of the pubis, and dorsal alopecia.
SIMILARITY: Belongs to the paired homeobox family.
SIMILARITY: Contains 1 homeobox DNA-binding domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  mRNA Secondary Structure of 3' and 5' UTRs
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+  Protein Domain and Structure Information
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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+  Gene Ontology (GO) Annotations with Structured Vocabulary
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-  Descriptions from all associated GenBank mRNAs
  BC049786 - Mus musculus aristaless-like homeobox 4, mRNA (cDNA clone IMAGE:6506755), with apparent retained intron.
AF001465 - Mus musculus paired-type homeodomain transcription factor (Alx4) mRNA, complete cds.
AB221573 - Mus musculus cDNA pooled tissues:(tissue_type=brain,dev_stage=8-12 days neonate,strain=BALB/c),(tissue_type=testis,dev_stage=adult, strain=C57BL/6J), clone:V01X007E15.

-  Other Names for This Gene
  Alternate Gene Symbols: ALX4_MOUSE, NM_007442, O35137, uc012bzt.1, uc012bzt.2
UCSC ID: uc012bzt.2
RefSeq Accession: NM_007442
Protein: O35137 (aka ALX4_MOUSE)
CCDS: CCDS16455.1

+  Gene Model Information
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.