Mouse Gene Prrx2 (ENSMUST00000041659.6) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus paired related homeobox 2 (Prrx2), mRNA. (from RefSeq NM_009116)
Gencode Transcript: ENSMUST00000041659.6
Gencode Gene: ENSMUSG00000039476.13
Transcript (Including UTRs)
   Position: mm10 chr2:30,845,059-30,881,251 Size: 36,193 Total Exon Count: 4 Strand: +
Coding Region
   Position: mm10 chr2:30,845,435-30,880,930 Size: 35,496 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr2:30,845,059-30,881,251)mRNA (may differ from genome)Protein (247 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
MGIPubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=Paired mesoderm homeobox protein 2; SubName: Full=Paired related homeobox 2;
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Contains 1 homeobox DNA-binding domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -177.60376-0.472 Picture PostScript Text
3' UTR -111.20321-0.346 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017970 - Homeobox_CS
IPR001356 - Homeodomain
IPR009057 - Homeodomain-like
IPR003654 - OAR_dom

Pfam Domains:
PF00046 - Homeobox domain
PF03826 - OAR domain

SCOP Domains:
46689 - Homeodomain-like

ModBase Predicted Comparative 3D Structure on A2APZ7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD Ensembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding

Biological Process:
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organism development

Cellular Component:
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  AK019971 - Mus musculus 8 days embryo whole body cDNA, RIKEN full-length enriched library, clone:5730524N22 product:paired related homeobox 2, full insert sequence.
X52875 - Mouse homeobox gene Prx2 mRNA.
BC137872 - Mus musculus paired related homeobox 2, mRNA (cDNA clone MGC:169496 IMAGE:8860891), complete cds.
BC137874 - Mus musculus paired related homeobox 2, mRNA (cDNA clone MGC:169498 IMAGE:8860893), complete cds.
X14572 - Mouse S8 mRNA containing homeo box.

-  Other Names for This Gene
  Alternate Gene Symbols: A2APZ7, A2APZ7_MOUSE, NM_009116, RP23-221O14.5-002, uc008jcy.1, uc008jcy.2, uc008jcy.3
UCSC ID: uc008jcy.3
RefSeq Accession: NM_009116
Protein: A2APZ7 CCDS: CCDS15888.1

+  Gene Model Information
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.