Mouse Gene Gbx2 (ENSMUST00000036954.8) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus gastrulation brain homeobox 2 (Gbx2), mRNA. (from RefSeq NM_010262)
Gencode Transcript: ENSMUST00000036954.8
Gencode Gene: ENSMUSG00000034486.8
Transcript (Including UTRs)
   Position: mm10 chr1:89,927,956-89,931,179 Size: 3,224 Total Exon Count: 2 Strand: -
Coding Region
   Position: mm10 chr1:89,928,620-89,930,755 Size: 2,136 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:89,927,956-89,931,179)mRNA (may differ from genome)Protein (348 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
MGIPubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Homeobox protein GBX-2; AltName: Full=Gastrulation and brain-specific homeobox protein 2; AltName: Full=Stimulated by retinoic acid gene 7 protein;
FUNCTION: May act as a transcription factor for cell pluripotency and differentiation in the embryo.
TISSUE SPECIFICITY: Expressed in adult brain, spleen and female genital tract. No expression in heart, liver, lung, kidney, or testis.
DEVELOPMENTAL STAGE: Expressed during gastrulation in the three primitive germ layers and in the pharyngeal arches. In later stages, expressed in the developing nervous system, midbrain/ hindbrain boundary, cerebellum anlage, certain rhombomeres, regions of the spinal cord, and in the developing dorsal thalamus and corpus striatum.
SIMILARITY: Contains 1 homeobox DNA-binding domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -211.50424-0.499 Picture PostScript Text
3' UTR -167.00664-0.252 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017970 - Homeobox_CS
IPR020479 - Homeobox_metazoa
IPR001356 - Homeodomain
IPR009057 - Homeodomain-like

Pfam Domains:
PF00046 - Homeobox domain

SCOP Domains:
101447 - Formin homology 2 domain (FH2 domain)
46689 - Homeodomain-like

ModBase Predicted Comparative 3D Structure on P48031
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding

Biological Process:
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001755 neural crest cell migration
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007411 axon guidance
GO:0008283 cell proliferation
GO:0021549 cerebellum development
GO:0021555 midbrain-hindbrain boundary morphogenesis
GO:0021568 rhombomere 2 development
GO:0021794 thalamus development
GO:0021884 forebrain neuron development
GO:0021930 cerebellar granule cell precursor proliferation
GO:0030902 hindbrain development
GO:0030917 midbrain-hindbrain boundary development
GO:0035239 tube morphogenesis
GO:0042472 inner ear morphogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048483 autonomic nervous system development

Cellular Component:
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  LF192780 - JP 2014500723-A/283: Polycomb-Associated Non-Coding RNAs.
BC050989 - Mus musculus gastrulation brain homeobox 2, mRNA (cDNA clone IMAGE:6333113).
LF216971 - JP 2014500723-A/24474: Polycomb-Associated Non-Coding RNAs.
L39770 - Mus musculus homeobox protein (Gbx-2) mRNA, complete cds.
Z48800 - M.musculus mRNA for Stra7 protein.
AK138361 - Mus musculus adult male hypothalamus cDNA, RIKEN full-length enriched library, clone:A230078E08 product:gastrulation brain homeobox 2, full insert sequence.
AK141657 - Mus musculus 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030011N21 product:gastrulation brain homeobox 2, full insert sequence.
LF216972 - JP 2014500723-A/24475: Polycomb-Associated Non-Coding RNAs.
BC116965 - Mus musculus gastrulation brain homeobox 2, mRNA (cDNA clone MGC:151342 IMAGE:40126284), complete cds.
BC120492 - Mus musculus gastrulation brain homeobox 2, mRNA (cDNA clone MGC:155729 IMAGE:40129415), complete cds.
AB221564 - Mus musculus cDNA pooled tissues:(tissue_type=brain,dev_stage=8-12 days neonate,strain=BALB/c),(tissue_type=testis,dev_stage=adult, strain=C57BL/6J), clone:V01X006C01.
LF216973 - JP 2014500723-A/24476: Polycomb-Associated Non-Coding RNAs.
LF216974 - JP 2014500723-A/24477: Polycomb-Associated Non-Coding RNAs.
LF202351 - JP 2014500723-A/9854: Polycomb-Associated Non-Coding RNAs.
LF192782 - JP 2014500723-A/285: Polycomb-Associated Non-Coding RNAs.
LF216978 - JP 2014500723-A/24481: Polycomb-Associated Non-Coding RNAs.
MA428357 - JP 2018138019-A/283: Polycomb-Associated Non-Coding RNAs.
MA452548 - JP 2018138019-A/24474: Polycomb-Associated Non-Coding RNAs.
MA452549 - JP 2018138019-A/24475: Polycomb-Associated Non-Coding RNAs.
MA452550 - JP 2018138019-A/24476: Polycomb-Associated Non-Coding RNAs.
MA452551 - JP 2018138019-A/24477: Polycomb-Associated Non-Coding RNAs.
MA437928 - JP 2018138019-A/9854: Polycomb-Associated Non-Coding RNAs.
MA428359 - JP 2018138019-A/285: Polycomb-Associated Non-Coding RNAs.
MA452555 - JP 2018138019-A/24481: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: GBX2_MOUSE, Mmoxa, NM_010262, P48031, Q14A66, Stra7, uc007bzb.1, uc007bzb.2
UCSC ID: uc007bzb.2
RefSeq Accession: NM_010262
Protein: P48031 (aka GBX2_MOUSE)
CCDS: CCDS15150.1

+  Gene Model Information
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-  Methods, Credits, and Use Restrictions
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