ID:GBX2_MOUSE DESCRIPTION: RecName: Full=Homeobox protein GBX-2; AltName: Full=Gastrulation and brain-specific homeobox protein 2; AltName: Full=Stimulated by retinoic acid gene 7 protein; FUNCTION: May act as a transcription factor for cell pluripotency and differentiation in the embryo. SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Expressed in adult brain, spleen and female genital tract. No expression in heart, liver, lung, kidney, or testis. DEVELOPMENTAL STAGE: Expressed during gastrulation in the three primitive germ layers and in the pharyngeal arches. In later stages, expressed in the developing nervous system, midbrain/ hindbrain boundary, cerebellum anlage, certain rhombomeres, regions of the spinal cord, and in the developing dorsal thalamus and corpus striatum. SIMILARITY: Contains 1 homeobox DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P48031
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0001569 branching involved in blood vessel morphogenesis GO:0001755 neural crest cell migration GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007411 axon guidance GO:0008283 cell proliferation GO:0021549 cerebellum development GO:0021555 midbrain-hindbrain boundary morphogenesis GO:0021568 rhombomere 2 development GO:0021794 thalamus development GO:0021884 forebrain neuron development GO:0021930 cerebellar granule cell precursor proliferation GO:0030902 hindbrain development GO:0030917 midbrain-hindbrain boundary development GO:0035239 tube morphogenesis GO:0042472 inner ear morphogenesis GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048483 autonomic nervous system development
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