Mouse Gene Isx (ENSMUST00000034034.9) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus intestine specific homeobox (Isx), transcript variant 2, mRNA. (from RefSeq NM_027837)
Gencode Transcript: ENSMUST00000034034.9
Gencode Gene: ENSMUSG00000031621.9
Transcript (Including UTRs)
   Position: mm10 chr8:74,873,173-74,893,506 Size: 20,334 Total Exon Count: 4 Strand: +
Coding Region
   Position: mm10 chr8:74,873,641-74,892,904 Size: 19,264 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr8:74,873,173-74,893,506)mRNA (may differ from genome)Protein (240 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
MGIPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=MCG14995; SubName: Full=Pancreas-intestine homeodomain transcription factor;
SUBCELLULAR LOCATION: Nucleus (By similarity).

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -157.80468-0.337 Picture PostScript Text
3' UTR -191.50602-0.318 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017970 - Homeobox_CS
IPR001356 - Homeodomain
IPR009057 - Homeodomain-like

Pfam Domains:
PF00046 - Homeobox domain

SCOP Domains:
46689 - Homeodomain-like

ModBase Predicted Comparative 3D Structure on B1Q2M1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding

Biological Process:
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  AK018615 - Mus musculus adult male cecum cDNA, RIKEN full-length enriched library, clone:9130012O13 product:weakly similar to HOMEODOMAIN PROTEIN (FRAGMENT) [Drosophila melanogaster], full insert sequence.
BC128289 - Mus musculus intestine specific homeobox, mRNA (cDNA clone MGC:150019 IMAGE:40102442), complete cds.
BC128290 - Mus musculus intestine specific homeobox, mRNA (cDNA clone MGC:150020 IMAGE:40102443), complete cds.
AB219124 - Mus musculus Pix-1 mRNA for pancreas-intestine homeodomain transcription factor, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: B1Q2M1, B1Q2M1_MOUSE, mCG_14995, NM_027837, Pix-1, uc009mgv.1, uc009mgv.2
UCSC ID: uc009mgv.2
RefSeq Accession: NM_027837
Protein: B1Q2M1 CCDS: CCDS40391.1

+  Gene Model Information
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.