Mouse Gene Isx (ENSMUST00000034034.9) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus intestine specific homeobox (Isx), transcript variant 2, mRNA. (from RefSeq NM_027837)
Gencode Transcript: ENSMUST00000034034.9
Gencode Gene: ENSMUSG00000031621.9
Transcript (Including UTRs)
   Position: mm10 chr8:74,873,173-74,893,506 Size: 20,334 Total Exon Count: 4 Strand: +
Coding Region
   Position: mm10 chr8:74,873,641-74,892,904 Size: 19,264 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:74,873,173-74,893,506)mRNA (may differ from genome)Protein (240 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
MGIPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: B1Q2M1_MOUSE
DESCRIPTION: SubName: Full=MCG14995; SubName: Full=Pancreas-intestine homeodomain transcription factor;
SUBCELLULAR LOCATION: Nucleus (By similarity).

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -157.80468-0.337 Picture PostScript Text
3' UTR -191.50602-0.318 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017970 - Homeobox_CS
IPR001356 - Homeodomain
IPR009057 - Homeodomain-like

Pfam Domains:
PF00046 - Homeobox domain

SCOP Domains:
46689 - Homeodomain-like

ModBase Predicted Comparative 3D Structure on B1Q2M1
FrontTopSide
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding

Biological Process:
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK018615 - Mus musculus adult male cecum cDNA, RIKEN full-length enriched library, clone:9130012O13 product:weakly similar to HOMEODOMAIN PROTEIN (FRAGMENT) [Drosophila melanogaster], full insert sequence.
BC128289 - Mus musculus intestine specific homeobox, mRNA (cDNA clone MGC:150019 IMAGE:40102442), complete cds.
BC128290 - Mus musculus intestine specific homeobox, mRNA (cDNA clone MGC:150020 IMAGE:40102443), complete cds.
AB219124 - Mus musculus Pix-1 mRNA for pancreas-intestine homeodomain transcription factor, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: B1Q2M1, B1Q2M1_MOUSE, mCG_14995, NM_027837, Pix-1, uc009mgv.1, uc009mgv.2
UCSC ID: uc009mgv.2
RefSeq Accession: NM_027837
Protein: B1Q2M1 CCDS: CCDS40391.1

+  Gene Model Information
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.