Mouse Gene Nobox (ENSMUST00000031749.15) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus NOBOX oogenesis homeobox (Nobox), mRNA. (from RefSeq NM_130869)
Gencode Transcript: ENSMUST00000031749.15
Gencode Gene: ENSMUSG00000029736.15
Transcript (Including UTRs)
   Position: mm10 chr6:43,303,674-43,309,554 Size: 5,881 Total Exon Count: 9 Strand: -
Coding Region
   Position: mm10 chr6:43,303,955-43,309,526 Size: 5,572 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:43,303,674-43,309,554)mRNA (may differ from genome)Protein (527 aa)
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-  Comments and Description Text from UniProtKB
  ID: NOBOX_MOUSE
DESCRIPTION: RecName: Full=Homeobox protein NOBOX; AltName: Full=Homeodomain-containing protein OG-2; AltName: Full=Newborn ovary homeobox protein; AltName: Full=Oocyte-specific homeobox protein;
FUNCTION: Transcription factor which plays an essential role in postnatal follicle development. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'. Directly regulates the transcription of POU5F1 aand GDF9 during early folliculogenesis.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Specifically expressed in ovaries and testes. In ovaries, expressed in oocytes from primordial through antral follicles but not in granulosa cells, theca cells and corpora lutea.
DEVELOPMENTAL STAGE: Expressed from E15.5.
DISRUPTION PHENOTYPE: Male mice are fertile and show no obvious abnormality. Female mice lacking Nobox have normal gross anatomy and histology, but are infertile with atrophic ovaries that lack oocytes at 6 weeks of age.
SIMILARITY: Contains 1 homeobox DNA-binding domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -11.3028-0.404 Picture PostScript Text
3' UTR -88.50281-0.315 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001356 - Homeodomain
IPR009057 - Homeodomain-like

Pfam Domains:
PF00046 - Homeobox domain

SCOP Domains:
46689 - Homeodomain-like

ModBase Predicted Comparative 3D Structure on Q8VIH1
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0043565 sequence-specific DNA binding

Biological Process:
GO:0001541 ovarian follicle development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007275 multicellular organism development
GO:0030154 cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048477 oogenesis

Cellular Component:
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AY061761 - Mus musculus newborn ovary homeodomain protein (Nobox) mRNA, complete cds.
BC125280 - Mus musculus NOBOX oogenesis homeobox, mRNA (cDNA clone MGC:158983 IMAGE:40129795), complete cds.
BC125282 - Mus musculus NOBOX oogenesis homeobox, mRNA (cDNA clone MGC:158985 IMAGE:40129797), complete cds.
AB221582 - Mus musculus cDNA pooled tissues:(tissue_type=brain,dev_stage=8-12 days neonate,strain=BALB/c),(tissue_type=testis,dev_stage=adult, strain=C57BL/6J), clone:V01X010E13.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_130869, NOBOX_MOUSE, Og2x, P70367, Q8VIH1, uc009bsp.1
UCSC ID: uc009bsp.1
RefSeq Accession: NM_130869
Protein: Q8VIH1 (aka NOBOX_MOUSE)
CCDS: CCDS20093.1

+  Gene Model Information
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-  Methods, Credits, and Use Restrictions
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