Mouse Gene Prrx1 (ENSMUST00000027878.13) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus paired related homeobox 1 (Prrx1), transcript variant 1, mRNA. (from RefSeq NM_011127)
Gencode Transcript: ENSMUST00000027878.13
Gencode Gene: ENSMUSG00000026586.16
Transcript (Including UTRs)
   Position: mm10 chr1:163,245,119-163,313,710 Size: 68,592 Total Exon Count: 4 Strand: -
Coding Region
   Position: mm10 chr1:163,248,258-163,312,635 Size: 64,378 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:163,245,119-163,313,710)mRNA (may differ from genome)Protein (245 aa)
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BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
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-  Comments and Description Text from UniProtKB
  ID: PRRX1_MOUSE
DESCRIPTION: RecName: Full=Paired mesoderm homeobox protein 1; AltName: Full=Homeobox protein K-2; AltName: Full=Homeobox protein mHox; AltName: Full=Paired-related homeobox protein 1; Short=PRX-1;
FUNCTION: Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Expressed exclusively in mesodermally derived cell types. During embryogenesis, highest levels of expression are found in the mesenchyme and precartilage elements of the face and hind limbs. In the adult, expression is restricted to skeletal muscle, heart and uterus.
DEVELOPMENTAL STAGE: Expressed during cardiogenesis.
SIMILARITY: Belongs to the paired homeobox family.
SIMILARITY: Contains 1 homeobox DNA-binding domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -351.301075-0.327 Picture PostScript Text
3' UTR -745.673139-0.238 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017970 - Homeobox_CS
IPR001356 - Homeodomain
IPR009057 - Homeodomain-like
IPR003654 - OAR_dom

Pfam Domains:
PF00046 - Homeobox domain
PF03826 - OAR domain

SCOP Domains:
46689 - Homeodomain-like

ModBase Predicted Comparative 3D Structure on P63013
FrontTopSide
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0071837 HMG box domain binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007275 multicellular organism development
GO:0030326 embryonic limb morphogenesis
GO:0042472 inner ear morphogenesis
GO:0042474 middle ear morphogenesis
GO:0045880 positive regulation of smoothened signaling pathway
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048664 neuron fate determination
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0048844 artery morphogenesis
GO:0051216 cartilage development
GO:0060021 palate development
GO:0070570 regulation of neuron projection regeneration
GO:0097150 neuronal stem cell population maintenance

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  BC092372 - Mus musculus paired related homeobox 1, mRNA (cDNA clone MGC:90699 IMAGE:30533016), complete cds.
BC060300 - Mus musculus cDNA clone IMAGE:30146418, partial cds.
BC024568 - Mus musculus paired related homeobox 1, mRNA (cDNA clone IMAGE:5030774), with apparent retained intron.
AK048023 - Mus musculus 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130030M18 product:unclassifiable, full insert sequence.
AK019503 - Mus musculus 0 day neonate skin cDNA, RIKEN full-length enriched library, clone:4632419J16 product:paired related homeobox 1, full insert sequence.
U03873 - Mus musculus homeobox (Pmx) mRNA, complete cds.
AK008112 - Mus musculus adult male small intestine cDNA, RIKEN full-length enriched library, clone:2010005A21 product:paired related homeobox 1, full insert sequence.
AK008428 - Mus musculus adult male small intestine cDNA, RIKEN full-length enriched library, clone:2010204A19 product:paired related homeobox 1, full insert sequence.
X59725 - M.musculus mRNA for homeobox gene.
L06502 - Mus musculus MHox protein mRNA, complete cds.
AB221686 - Mus musculus cDNA pooled tissues:(tissue_type=brain,dev_stage=8-12 days neonate,strain=BALB/c),(tissue_type=testis,dev_stage=adult, strain=C57BL/6J), clone:V01Y050E23.
AK031075 - Mus musculus 13 days embryo forelimb cDNA, RIKEN full-length enriched library, clone:5930402I12 product:PAIRED MESODERM HOMEOBOX PROTEIN 1 (PRX-1) (PAIRED RELATED HOMEOBOX PROTEIN 1) (HOMEOBOX PROTEIN MHOX) (HOMEOBOX PROTEIN K-2) (RHOX) homolog [Mus musculus], full insert sequence.
AK089006 - Mus musculus 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430035F19 product:paired related homeobox 1, full insert sequence.
AK032773 - Mus musculus 12 days embryo male wolffian duct includes surrounding region cDNA, RIKEN full-length enriched library, clone:6720434F24 product:paired related homeobox 1, full insert sequence.
AK165914 - Mus musculus lung RCB-0558 LLC cDNA, RIKEN full-length enriched library, clone:G730018L19 product:paired related homeobox 1, full insert sequence.
AK084387 - Mus musculus 12 days embryo eyeball cDNA, RIKEN full-length enriched library, clone:D230035K19 product:PAIRED MESODERM HOMEOBOX PROTEIN 1 (PRX-1) (PAIRED RELATED HOMEOBOX PROTEIN 1) (HOMEOBOX PROTEIN MHOX) (HOMEOBOX PROTEIN K-2) (RHOX) homolog [Mus musculus], full insert sequence.
AK029347 - Mus musculus 0 day neonate head cDNA, RIKEN full-length enriched library, clone:4833401H05 product:unclassifiable, full insert sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_011127, P43271, P63013, Pmx, Pmx1, PRRX1_MOUSE, Q02810, Q569N6, uc007dhi.1, uc007dhi.2
UCSC ID: uc007dhi.2
RefSeq Accession: NM_011127
Protein: P63013 (aka PRRX1_MOUSE)
CCDS: CCDS15427.1

+  Gene Model Information
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-  Methods, Credits, and Use Restrictions
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