Mouse Gene Mixl1 (ENSMUST00000027778.7) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus Mix1 homeobox-like 1 (Xenopus laevis) (Mixl1), mRNA. (from RefSeq NM_013729)
Gencode Transcript: ENSMUST00000027778.7
Gencode Gene: ENSMUSG00000026497.7
Transcript (Including UTRs)
   Position: mm10 chr1:180,693,043-180,697,034 Size: 3,992 Total Exon Count: 2 Strand: -
Coding Region
   Position: mm10 chr1:180,694,619-180,697,012 Size: 2,394 Coding Exon Count: 2 

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Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:180,693,043-180,697,034)mRNA (may differ from genome)Protein (231 aa)
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-  Comments and Description Text from UniProtKB
  ID: MIXL1_MOUSE
DESCRIPTION: RecName: Full=Homeobox protein MIXL1; AltName: Full=Homeodomain protein MIX; Short=mMix; AltName: Full=MIX1 homeobox-like protein 1; AltName: Full=Mix.1 homeobox-like protein;
FUNCTION: Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Expressed in the primitive streak of the gastrulating embryo, and marks cells destined to form mesoderm and endoderm. Present in differentiating embryonic stem cells (at protein level).
DEVELOPMENTAL STAGE: Initially expressed in visceral endoderm and becomes restricted to primitive streak and nascent mesoderm at gastrulation. This includes the hemangioblast, a precursor of hematopoietic and vascular stem cells. At E5.5, it is expressed symmetrically in the visceral endoderm but by E6.0 this expression is noticeably asymmetric. At E6.5, expression is restricted to the nascent primitive streak and persists in the primitive streak through E7.5-E9.5, marking those cells fated to form extra- embryonic and lateral mesoderm.
INDUCTION: By TGF-beta. Regulated by Nodal in mesendoderm morphogenesis. Regulated by FOXH1, which acts as a negative regulator by recruiting GSC to promoter during early development.
DISRUPTION PHENOTYPE: Mice display defects in mesendoderm morphogenesis and patterning during development. Embryos show a marked thickening of the primitive streak. By the early somite stage, embryonic development is arrested, with the formation of abnormal head folds, foreshortened body axis, absence of heart tube and gut, deficient paraxial mesoderm, and an enlarged midline tissue mass that replaces the notochord. Development of extra- embryonic structures is generally normal except that the allantois is often disproportionately large for the size of the mutant embryo.
SIMILARITY: Belongs to the paired homeobox family.
SIMILARITY: Contains 1 homeobox DNA-binding domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  mRNA Secondary Structure of 3' and 5' UTRs
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+  Protein Domain and Structure Information
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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+  Gene Ontology (GO) Annotations with Structured Vocabulary
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-  Descriptions from all associated GenBank mRNAs
  AF154573 - Mus musculus homeobox protein MIX (MIx) mRNA, complete cds.
AK138043 - Mus musculus 16 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A130076O20 product:Mix1 homeobox-like 1 (Xenopus laevis), full insert sequence.
AF201959 - Mus musculus Mix-related homeobox protein mRNA, partial cds.
BC099877 - Mus musculus Mix1 homeobox-like 1 (Xenopus laevis), mRNA (cDNA clone MGC:123453 IMAGE:40040048), complete cds.
BC099876 - Mus musculus Mix1 homeobox-like 1 (Xenopus laevis), mRNA (cDNA clone MGC:123452 IMAGE:40040047), complete cds.
AB221547 - Mus musculus cDNA pooled tissues:(tissue_type=brain,dev_stage=8-12 days neonate,strain=BALB/c),(tissue_type=testis,dev_stage=adult, strain=C57BL/6J), clone:V01X003C05.
AF135063 - Mus musculus Mix-like homeobox protein (Mml) mRNA, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: Mix, MIXL1_MOUSE, Mml, NM_013729, Q9QZ61, Q9WUI0, uc007dwp.1, uc007dwp.2
UCSC ID: uc007dwp.2
RefSeq Accession: NM_013729
Protein: Q9WUI0 (aka MIXL1_MOUSE)
CCDS: CCDS15571.1

+  Gene Model Information
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-  Methods, Credits, and Use Restrictions
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