Mouse Gene Gsc (ENSMUST00000021513.5) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus goosecoid homeobox (Gsc), mRNA. (from RefSeq NM_010351)
Gencode Transcript: ENSMUST00000021513.5
Gencode Gene: ENSMUSG00000021095.5
Transcript (Including UTRs)
   Position: mm10 chr12:104,471,209-104,473,330 Size: 2,122 Total Exon Count: 3 Strand: -
Coding Region
   Position: mm10 chr12:104,471,491-104,473,115 Size: 1,625 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:104,471,209-104,473,330)mRNA (may differ from genome)Protein (256 aa)
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BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
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-  Comments and Description Text from UniProtKB
  ID: GSC_MOUSE
DESCRIPTION: RecName: Full=Homeobox protein goosecoid;
FUNCTION: Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis (By similarity). In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Goosecoid-expressing regions of the gastrulating mouse egg cylinder have organizer-like activity when transplanted into Xenopus embryos.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: In early gastrulation, expressed in the dorsal lip. In later stages of development found in head, limbs and body wall.
INDUCTION: By activin.
SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
SIMILARITY: Contains 1 homeobox DNA-binding domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -110.30215-0.513 Picture PostScript Text
3' UTR -113.00282-0.401 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017970 - Homeobox_CS
IPR001356 - Homeodomain
IPR009057 - Homeodomain-like

Pfam Domains:
PF00046 - Homeobox domain

SCOP Domains:
81822 - RuBisCo LSMT C-terminal, substrate-binding domain
46689 - Homeodomain-like
53613 - Ribokinase-like

ModBase Predicted Comparative 3D Structure on Q02591
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001085 RNA polymerase II transcription factor binding
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organism development
GO:0009653 anatomical structure morphogenesis
GO:0014036 neural crest cell fate specification
GO:0021904 dorsal/ventral neural tube patterning
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030900 forebrain development
GO:0042474 middle ear morphogenesis
GO:0043583 ear development
GO:0048644 muscle organ morphogenesis
GO:0048704 embryonic skeletal system morphogenesis

Cellular Component:
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0016604 nuclear body


-  Descriptions from all associated GenBank mRNAs
  Y13149 - Mus musculus mRNA for goosecoid homeobox protein, clone cDNA-D.
Y13150 - Mus musculus mRNA for goosecoid homeobox protein, clone cDNA-E.
X99239 - M.muscsulus mRNA for goosecoid homeobox.
AB221548 - Mus musculus cDNA pooled tissues:(tissue_type=brain,dev_stage=8-12 days neonate,strain=BALB/c),(tissue_type=testis,dev_stage=adult, strain=C57BL/6J), clone:V01X003I13.
BC160213 - Synthetic construct Mus musculus clone IMAGE:100063861, MGC:193328 goosecoid homeobox (Gsc) mRNA, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: GSC_MOUSE, NM_010351, Q02591, uc007oxh.1, uc007oxh.2
UCSC ID: uc007oxh.2
RefSeq Accession: NM_010351
Protein: Q02591 (aka GSC_MOUSE)
CCDS: CCDS26153.1

+  Gene Model Information
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-  Methods, Credits, and Use Restrictions
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