ID:GHC1_MOUSE DESCRIPTION: RecName: Full=Mitochondrial glutamate carrier 1; Short=GC-1; AltName: Full=Glutamate/H(+) symporter 1; AltName: Full=Solute carrier family 25 member 22; FUNCTION: Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+) (By similarity). SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein (Potential). SIMILARITY: Belongs to the mitochondrial carrier family. SIMILARITY: Contains 3 Solcar repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9D6M3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF196693 - JP 2014500723-A/4196: Polycomb-Associated Non-Coding RNAs. BC037949 - Mus musculus solute carrier family 25 (mitochondrial carrier, glutamate), member 22, mRNA (cDNA clone MGC:40783 IMAGE:5367108), complete cds. BC050887 - Mus musculus solute carrier family 25 (mitochondrial carrier, glutamate), member 22, mRNA (cDNA clone IMAGE:5708744), complete cds. AK162400 - Mus musculus adult male diencephalon cDNA, RIKEN full-length enriched library, clone:9330153M07 product:solute carrier family 25 (mitochondrial carrier: glutamate), member 22, full insert sequence. AK158985 - Mus musculus visual cortex cDNA, RIKEN full-length enriched library, clone:K530024H12 product:unclassifiable, full insert sequence. AK048389 - Mus musculus 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130055F24 product:NT2RP3001355 PROTEIN homolog [Homo sapiens], full insert sequence. AK010193 - Mus musculus adult male tongue cDNA, RIKEN full-length enriched library, clone:2310076D23 product:weakly similar to SOLUTE CARRIER [Homo sapiens], full insert sequence. AK046874 - Mus musculus 10 days neonate medulla oblongata cDNA, RIKEN full-length enriched library, clone:B830043K10 product:NT2RP3001355 PROTEIN homolog [Homo sapiens], full insert sequence. AK018760 - Mus musculus adult male liver cDNA, RIKEN full-length enriched library, clone:1300006L01 product:hypothetical Mitochondrial energy transfer proteins (carrier protein) containing protein, full insert sequence. AK155276 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630213M12 product:solute carrier family 25 (mitochondrial carrier: glutamate), member 22, full insert sequence. AK049313 - Mus musculus ES cells cDNA, RIKEN full-length enriched library, clone:C330021P11 product:weakly similar to SOLUTE CARRIER [Homo sapiens], full insert sequence. LF296629 - JP 2014500723-A/104132: Polycomb-Associated Non-Coding RNAs. LF296630 - JP 2014500723-A/104133: Polycomb-Associated Non-Coding RNAs. AK187553 - Mus musculus cDNA, clone:Y0G0142D24, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000019226, based on BLAT search. AK181898 - Mus musculus cDNA, clone:Y0G0120A07, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000019226, based on BLAT search. LF296632 - JP 2014500723-A/104135: Polycomb-Associated Non-Coding RNAs. MA432270 - JP 2018138019-A/4196: Polycomb-Associated Non-Coding RNAs. MA532206 - JP 2018138019-A/104132: Polycomb-Associated Non-Coding RNAs. MA532207 - JP 2018138019-A/104133: Polycomb-Associated Non-Coding RNAs. MA532209 - JP 2018138019-A/104135: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9D6M3 (Reactome details) participates in the following event(s):
R-MMU-8875623 SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix R-MMU-428643 Organic anion transporters R-MMU-425374 Amino acid and oligopeptide SLC transporters R-MMU-425393 Metabolism of nitrogenous molecules R-MMU-425407 SLC-mediated transmembrane transport R-MMU-382551 Transport of small molecules
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