ID:PAX5_MOUSE DESCRIPTION: RecName: Full=Paired box protein Pax-5; AltName: Full=B-cell-specific transcription factor; Short=BSAP; FUNCTION: May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene. SUBUNIT: Interacts with ETS1, altering its DNA-binding properties (By similarity). Interacts with DAXX and TLE4. Binds DNA as a monomer. INTERACTION: Q9UER7:DAXX (xeno); NbExp=4; IntAct=EBI-296260, EBI-77321; SUBCELLULAR LOCATION: Nucleus. DEVELOPMENTAL STAGE: Expressed at early B-cell differentiation, in the developing CNS and in adult testis. PTM: O-glycosylated (Probable). SIMILARITY: Contains 1 paired domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0007283 spermatogenesis GO:0007399 nervous system development GO:0007568 aging GO:0009887 animal organ morphogenesis GO:0021670 lateral ventricle development GO:0021987 cerebral cortex development GO:0030154 cell differentiation GO:0030534 adult behavior GO:0035914 skeletal muscle cell differentiation GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048701 embryonic cranial skeleton morphogenesis GO:0051573 negative regulation of histone H3-K9 methylation GO:0071542 dopaminergic neuron differentiation
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