Mouse Gene Pax6 (ENSMUST00000111086.10) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus paired box 6 (Pax6), transcript variant 1, mRNA. (from RefSeq NM_001244198)
RefSeq Summary (NM_001244198): This gene encodes a homeobox-containing protein that functions as a regulator of transcription. It plays a key role in the development of neural tissues, particularly the eye. Activity of this protein is also required for expression of glucagon in the pancreas. This gene is regulated by multiple enhancers located up to tens or hundreds of kilobases upstream and downstream of the transcription start sites. Mutations in this gene or deletion of these regulatory elements results in severe defects in eye development. Alternative splicing and the use of alternative promoters results in multiple transcript variants, some of which encode proteins that lack the N-terminal paired domain. [provided by RefSeq, Jul 2015].
Gencode Transcript: ENSMUST00000111086.10
Gencode Gene: ENSMUSG00000027168.21
Transcript (Including UTRs)
   Position: mm10 chr2:105,668,900-105,697,364 Size: 28,465 Total Exon Count: 13 Strand: +
Coding Region
   Position: mm10 chr2:105,680,298-105,696,355 Size: 16,058 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-20

+  Sequence and Links to Tools and Databases
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+  Comments and Description Text from UniProtKB
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+  Comparative Toxicogenomics Database (CTD)
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -87.50281-0.311 Picture PostScript Text
3' UTR -236.501009-0.234 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

+  Protein Domain and Structure Information
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+  Orthologous Genes in Other Species
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+  Gene Ontology (GO) Annotations with Structured Vocabulary
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-  Descriptions from all associated GenBank mRNAs
  AK028059 - Mus musculus adult male cerebellum cDNA, RIKEN full-length enriched library, clone:1500038E17 product:paired box gene 6, full insert sequence.
AK032616 - Mus musculus adult male olfactory brain cDNA, RIKEN full-length enriched library, clone:6430706M13 product:paired box gene 6, full insert sequence.
BC036957 - Mus musculus paired box gene 6, mRNA (cDNA clone MGC:46875 IMAGE:4504106), complete cds.
AF457141 - Mus musculus Pax6 paired-less isoform mRNA, complete cds.
AF457142 - Mus musculus Pax6 protein isoform mRNA, complete cds; alternatively spliced.
BC069912 - Mus musculus paired box gene 6, mRNA (cDNA clone IMAGE:6309201).
AY064175 - Mus musculus Pax6 paired-less isoform mRNA, complete cds.
X63963 - M.musculus pax-6 mRNA for paired box protein.
AK045805 - Mus musculus adult male corpora quadrigemina cDNA, RIKEN full-length enriched library, clone:B230311L02 product:paired box gene 6, full insert sequence.
BC011272 - Mus musculus paired box gene 6, mRNA (cDNA clone MGC:18454 IMAGE:4008490), complete cds.
AJ292077 - Mus musculus partial mRNA for paired box protein (Pax6 gene), clone PAX6-9Neu.
AJ307468 - Mus musculus mRNA for paired box protein (Pax-6 gene).
AF443223 - Mus musculus PAX6 mRNA, partial cds, alternatively spliced.
M77842 - Mus musculus oculorhombin (Sey) mRNA, complete cds.
AK139054 - Mus musculus 7 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:A730006J20 product:paired box gene 6, full insert sequence.
HW661303 - JP 2014522668-A/27: DOWNREGULATION OF miR-7 FOR PROMOTION OF BETA CELL DIFFERENTIATION AND INSULIN PRODUCTION.
JC277325 - Sequence 27 from Patent WO2013021389.
KX987998 - UNVERIFIED: Mus musculus strain AKR paired box 6-like mRNA, complete sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04950 - Maturity onset diabetes of the young

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001244198, P32117, P63015, P70601, Pax-6, PAX6_MOUSE, Q62222, Q64037, Q8CEI5, Q8VDB5, Q921Q8, Sey, uc008lku.1, uc008lku.2, uc008lku.3, uc008lku.4
UCSC ID: uc008lku.4
RefSeq Accession: NM_001244198
Protein: P63015 (aka PAX6_MOUSE)
CCDS: CCDS16499.1, CCDS57181.1

-  Gene Model Information
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+  Methods, Credits, and Use Restrictions
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