ID:PAX4_MOUSE DESCRIPTION: RecName: Full=Paired box protein Pax-4; FUNCTION: Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that competes with PAX6 in binding to a common element in the glucagon, insulin and somatostatin promoters. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in early pancreas. Later restricted to beta cells. Undetectable in adult islets. SIMILARITY: Belongs to the paired homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain. SIMILARITY: Contains 1 paired domain.
ModBase Predicted Comparative 3D Structure on P32115
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003677 DNA binding GO:0003690 double-stranded DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0007275 multicellular organism development GO:0007623 circadian rhythm GO:0009887 animal organ morphogenesis GO:0030154 cell differentiation GO:0031016 pancreas development GO:0031018 endocrine pancreas development GO:0042493 response to drug GO:0043066 negative regulation of apoptotic process GO:0045595 regulation of cell differentiation GO:0045597 positive regulation of cell differentiation GO:0045892 negative regulation of transcription, DNA-templated GO:0051591 response to cAMP GO:0060041 retina development in camera-type eye
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Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu04950 - Maturity onset diabetes of the young
Reactome (by CSHL, EBI, and GO)
Protein P32115 (Reactome details) participates in the following event(s):
R-MMU-186574 Endocrine-committed (Ngn3+) progenitor cells R-MMU-210774 Regulation of Beta-Cell Development R-MMU-210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells R-MMU-186574 Endocrine-committed (Ngn3+) progenitor cells R-MMU-186712 Regulation of beta-cell development R-MMU-210774 Regulation of Beta-Cell Development R-MMU-1266738 Developmental Biology R-MMU-186574 Endocrine-committed (Ngn3+) progenitor cells R-MMU-210774 Regulation of Beta-Cell Development
Other Names for This Gene
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Gene Model Information
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
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