Mouse Gene Pax4 (ENSMUST00000031718.13) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus paired box 4 (Pax4), transcript variant 1, mRNA. (from RefSeq NM_011038)
Gencode Transcript: ENSMUST00000031718.13
Gencode Gene: ENSMUSG00000029706.15
Transcript (Including UTRs)
   Position: mm10 chr6:28,442,334-28,449,353 Size: 7,020 Total Exon Count: 11 Strand: -
Coding Region
   Position: mm10 chr6:28,442,378-28,447,133 Size: 4,756 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr6:28,442,334-28,449,353)mRNA (may differ from genome)Protein (349 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Paired box protein Pax-4;
FUNCTION: Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that competes with PAX6 in binding to a common element in the glucagon, insulin and somatostatin promoters.
TISSUE SPECIFICITY: Expressed in early pancreas. Later restricted to beta cells. Undetectable in adult islets.
SIMILARITY: Belongs to the paired homeobox family.
SIMILARITY: Contains 1 homeobox DNA-binding domain.
SIMILARITY: Contains 1 paired domain.

-  Primer design for this transcript

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  mRNA Secondary Structure of 3' and 5' UTRs
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-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017970 - Homeobox_CS
IPR001356 - Homeodomain
IPR009057 - Homeodomain-like
IPR001523 - Paired_dom
IPR011991 - WHTH_trsnscrt_rep_DNA-bd

Pfam Domains:
PF00046 - Homeobox domain
PF00292 - 'Paired box' domain

SCOP Domains:
46689 - Homeodomain-like
46785 - "Winged helix" DNA-binding domain
46894 - C-terminal effector domain of the bipartite response regulators

ModBase Predicted Comparative 3D Structure on P32115
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0043565 sequence-specific DNA binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organism development
GO:0007623 circadian rhythm
GO:0009887 animal organ morphogenesis
GO:0030154 cell differentiation
GO:0031016 pancreas development
GO:0031018 endocrine pancreas development
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0045595 regulation of cell differentiation
GO:0045597 positive regulation of cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0051591 response to cAMP
GO:0060041 retina development in camera-type eye

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex

+  Descriptions from all associated GenBank mRNAs
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-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04950 - Maturity onset diabetes of the young

Reactome (by CSHL, EBI, and GO)

Protein P32115 (Reactome details) participates in the following event(s):

R-MMU-186574 Endocrine-committed (Ngn3+) progenitor cells
R-MMU-210774 Regulation of Beta-Cell Development
R-MMU-210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
R-MMU-186574 Endocrine-committed (Ngn3+) progenitor cells
R-MMU-186712 Regulation of beta-cell development
R-MMU-210774 Regulation of Beta-Cell Development
R-MMU-1266738 Developmental Biology
R-MMU-186574 Endocrine-committed (Ngn3+) progenitor cells
R-MMU-210774 Regulation of Beta-Cell Development

+  Other Names for This Gene
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+  Gene Model Information
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.