Mouse Gene Slc25a45 (ENSMUST00000125114.7) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). (from UniProt Q8CFJ7)
Gencode Transcript: ENSMUST00000125114.7
Gencode Gene: ENSMUSG00000024818.15
Transcript (Including UTRs)
   Position: mm10 chr19:5,877,817-5,885,766 Size: 7,950 Total Exon Count: 5 Strand: +
Coding Region
   Position: mm10 chr19:5,878,655-5,884,644 Size: 5,990 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:5,877,817-5,885,766)mRNA (may differ from genome)Protein (212 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsMGIPubMed
SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: S2545_MOUSE
DESCRIPTION: RecName: Full=Solute carrier family 25 member 45;
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the mitochondrial carrier family.
SIMILARITY: Contains 3 Solcar repeats.
SEQUENCE CAUTION: Sequence=AAH22156.1; Type=Erroneous initiation; Sequence=BAE42082.1; Type=Frameshift; Positions=259;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -318.30838-0.380 Picture PostScript Text
3' UTR -399.201122-0.356 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002067 - Mit_carrier
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom

Pfam Domains:
PF00153 - Mitochondrial carrier protein

SCOP Domains:
103506 - Mitochondrial carrier

ModBase Predicted Comparative 3D Structure on Q8CFJ7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0022857 transmembrane transporter activity
GO:0000064 L-ornithine transmembrane transporter activity

Biological Process:
GO:0006839 mitochondrial transport
GO:0055085 transmembrane transport

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK133879 - Mus musculus 8 days embryo whole body cDNA, RIKEN full-length enriched library, clone:5730478M19 product:hypothetical Mitochondrial substrate carrier containing protein, full insert sequence.
AK155754 - Mus musculus B6-derived CD11 +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F730216B10 product:hypothetical Adenine nucleotide translocator 1/Mitochondrial carrier protein/Mitochondrial substrate carrier containing protein, full insert sequence.
AK169876 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630002E17 product:hypothetical Adenine nucleotide translocator 1/Mitochondrial carrier protein/Mitochondrial substrate carrier containing protein, full insert sequence.
AK170869 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630206H20 product:hypothetical Mitochondrial carrier protein/Mitochondrial substrate carrier containing protein, full insert sequence.
BC037680 - Mus musculus solute carrier family 25, member 45, mRNA (cDNA clone MGC:47212 IMAGE:3481846), complete cds.
BC022156 - Mus musculus solute carrier family 25, member 45, mRNA (cDNA clone IMAGE:5133804), partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: AK133879, Q3TC75, Q3UZE9, Q8CFJ7, Q8VBZ7, S2545_MOUSE, uc008gfr.1, uc008gfr.2
UCSC ID: uc008gfr.2
RefSeq Accession: NM_134154
Protein: Q8CFJ7 (aka S2545_MOUSE)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.