ID:ADT1_MOUSE DESCRIPTION: RecName: Full=ADP/ATP translocase 1; AltName: Full=ADP,ATP carrier protein 1; AltName: Full=ADP,ATP carrier protein, heart/skeletal muscle isoform T1; AltName: Full=Adenine nucleotide translocator 1; Short=ANT 1; AltName: Full=Solute carrier family 25 member 4; AltName: Full=mANC1; FUNCTION: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. SUBUNIT: Homodimer. Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with ARL2BP. SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein. Note=The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria. MISCELLANEOUS: The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity). SIMILARITY: Belongs to the mitochondrial carrier family. SIMILARITY: Contains 3 Solcar repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P48962
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0008637 apoptotic mitochondrial changes GO:0010667 negative regulation of cardiac muscle cell apoptotic process GO:0015866 ADP transport GO:0015867 ATP transport GO:0046902 regulation of mitochondrial membrane permeability GO:0055085 transmembrane transport GO:0060546 negative regulation of necroptotic process GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process GO:2000277 positive regulation of oxidative phosphorylation uncoupler activity
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