Description: Homo sapiens X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound (XPNPEP2), mRNA. RefSeq Summary (NM_003399): Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chrX:128,872,946-128,882,057 Size: 9,112 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chrX:128,873,190-128,881,857 Size: 8,668 Coding Exon Count: 7
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): XPNPEP2 CDC HuGE Published Literature: XPNPEP2 Positive Disease Associations: angioedema Related Studies:
angioedema Duan, Q. L. et al. 2005, A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors., American journal of human genetics. 2005 Oct;77(4):617-26.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on B4DV70
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.