Rat Gene Slc25a21 (RGD:621444)
  Description: mitochondrial oxodicarboxylate carrier; involved in the transport C5-C7 oxodicarboxylates across the inner membranes of mitochondria
Transcript (Including UTRs)
   Position: rn4 chr6:77,124,451-77,632,510 Size: 508,060 Total Exon Count: 9 Strand: -
Coding Region
   Position: rn4 chr6:77,125,738-77,632,255 Size: 506,518 Coding Exon Count: 9 

Page IndexSequence and LinksRGD Gene DataUniProtKB CommentsPrimersCTD
Microarray ExpressionProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated at UCSC: 2011-12-07

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr6:77,124,451-77,632,510)mRNAProtein (298 aa)
Gene SorterOther Species FASTAAlphaFoldEnsemblEntrez GeneGeneNetwork

-  Additional Data from RGD
  RGD Gene: 621444
Gene Symbol: Slc25a21
Name: solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21
Curated Pubmed Papers: 11083877, 12477932, 15489334
Uncurated Pubmed Papers: 727306
Entrez Gene: 171151
UniProt: Q99JD3
GenBank Nucleotide: AJ289714, BC089099, NM_133614, CH473947
Genebank Protein: NP_598298.1, AAH89099, CAC27796, EDM03446, NP_598298, Q99JD3
UniGene: 205044
Ensembl Gene: ENSRNOG00000008931
IMAGE CLONE: 7306738
MGC: BC089099

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Mitochondrial 2-oxodicarboxylate carrier; AltName: Full=Solute carrier family 25 member 21;
FUNCTION: Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2- oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate.
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the mitochondrial carrier family.
SIMILARITY: Contains 3 Solcar repeats.

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
Expression ratio colors:

Affymetrix All Exon Microarrays


-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom

Pfam Domains:
PF00153 - Mitochondrial carrier protein

ModBase Predicted Comparative 3D Structure on Q99JD3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
  Protein SequenceProtein SequenceProtein SequenceProtein Sequence

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005310 dicarboxylic acid transmembrane transporter activity

Biological Process:
GO:0006835 dicarboxylic acid transport
GO:0006839 mitochondrial transport

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  BC089099 - Rattus norvegicus solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21, mRNA (cDNA clone MGC:105329 IMAGE:7306738), complete cds.
AJ289714 - Rattus norvegicus mRNA for mitochondrial oxodicarboxylate carrier (odc gene).

-  Other Names for This Gene
  Symbol: MGC105329, Odc1
Name: mitochondrial 2-oxodicarboxylate carrier, oxodicarboxylate carrier, solute carrier family 25 member 21
RefSeq Accession: NM_133614
Protein: Q99JD3 (aka ODC_RAT)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.