Human Gene PIK3CD (ENST00000698709.1) from GENCODE V44
Description: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta (from HGNC PIK3CD)
RefSeq Summary (NM_005026): Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010].
Gencode Transcript: ENST00000698709.1
Gencode Gene: ENSG00000171608.18
Transcript (Including UTRs)
Position: hg38 chr1:9,651,744-9,728,906 Size: 77,163 Total Exon Count: 24 Strand: +
Position: hg38 chr1:9,710,456-9,727,046 Size: 16,591 Coding Exon Count: 22
Data last updated at UCSC: 2023-08-18 09:09:47
Sequence and Links to Tools and Databases
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
AK314191 - Homo sapiens cDNA, FLJ94916, highly similar to Homo sapiens phosphoinositide-3-kinase, catalytic, delta polypeptide (PIK3CD), mRNA. U86453 - Human phosphatidylinositol 3-kinase catalytic subunit p110delta mRNA, complete cds. Y10055 - Homo sapiens mRNA for phosphoinositide 3-kinase. BC030263 - Homo sapiens phosphoinositide-3-kinase, catalytic, delta polypeptide, mRNA (cDNA clone IMAGE:5215630), with apparent retained intron. BC150297 - Homo sapiens phosphoinositide-3-kinase, catalytic, delta polypeptide, mRNA (cDNA clone MGC:167031 IMAGE:8860364), complete cds. BC132919 - Homo sapiens phosphoinositide-3-kinase, catalytic, delta polypeptide, mRNA (cDNA clone MGC:164550 IMAGE:40146941), complete cds. BC132921 - Homo sapiens phosphoinositide-3-kinase, catalytic, delta polypeptide, mRNA (cDNA clone MGC:164552 IMAGE:40146943), complete cds. BC144264 - Homo sapiens phosphoinositide-3-kinase, catalytic, delta polypeptide, mRNA (cDNA clone MGC:177801 IMAGE:9052784), complete cds. JN190435 - Homo sapiens phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta (PIK3CD) mRNA, complete cds, alternatively spliced. JD443472 - Sequence 424496 from Patent EP1572962. JD139324 - Sequence 120348 from Patent EP1572962. JD268316 - Sequence 249340 from Patent EP1572962. JD473056 - Sequence 454080 from Patent EP1572962. JD446015 - Sequence 427039 from Patent EP1572962. U57843 - Human phosphatidylinositol 3-kinase delta catalytic subunit mRNA, complete cds. KJ891810 - Synthetic construct Homo sapiens clone ccsbBroadEn_01204 PIK3CD gene, encodes complete protein. KR712001 - Synthetic construct Homo sapiens clone CCSBHm_00034604 PIK3CD (PIK3CD) mRNA, encodes complete protein. KU612116 - Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta (PIK3CD) mRNA, complete cds, alternatively spliced. KU612117 - Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta short variant 20 (PIK3CD) mRNA, complete cds, alternatively spliced. KU612118 - Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta short variant 8 (PIK3CD) mRNA, complete cds, alternatively spliced. KU612119 - Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta short variant 8/20 (PIK3CD) mRNA, complete cds, alternatively spliced. DQ263594 - Homo sapiens phosphoinositide-3-kinase B mRNA, complete cds. DQ263595 - Homo sapiens phosphoinositide-3-kinase C mRNA, complete cds. DQ263596 - Homo sapiens phosphoinositide-3-kinase D mRNA, complete cds. AB208835 - Homo sapiens mRNA for phosphoinositide-3-kinase, catalytic, delta polypeptide variant protein. AK303425 - Homo sapiens cDNA FLJ51430 complete cds, highly similar to Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 184.108.40.206). JD380563 - Sequence 361587 from Patent EP1572962. JD076432 - Sequence 57456 from Patent EP1572962. JD168131 - Sequence 149155 from Patent EP1572962. JD452105 - Sequence 433129 from Patent EP1572962. JD494415 - Sequence 475439 from Patent EP1572962. JD163538 - Sequence 144562 from Patent EP1572962. JD190045 - Sequence 171069 from Patent EP1572962. JD187247 - Sequence 168271 from Patent EP1572962. JD183500 - Sequence 164524 from Patent EP1572962. JD482322 - Sequence 463346 from Patent EP1572962. JD104475 - Sequence 85499 from Patent EP1572962. JD373965 - Sequence 354989 from Patent EP1572962. JD566884 - Sequence 547908 from Patent EP1572962. JD531757 - Sequence 512781 from Patent EP1572962. JD333234 - Sequence 314258 from Patent EP1572962. JD089090 - Sequence 70114 from Patent EP1572962. JD218794 - Sequence 199818 from Patent EP1572962. JD099253 - Sequence 80277 from Patent EP1572962. JD441719 - Sequence 422743 from Patent EP1572962. JD448901 - Sequence 429925 from Patent EP1572962. JD221815 - Sequence 202839 from Patent EP1572962. JD201988 - Sequence 183012 from Patent EP1572962. JD168319 - Sequence 149343 from Patent EP1572962. JD410574 - Sequence 391598 from Patent EP1572962. JD535223 - Sequence 516247 from Patent EP1572962. JD241560 - Sequence 222584 from Patent EP1572962. JD515126 - Sequence 496150 from Patent EP1572962. JD163192 - Sequence 144216 from Patent EP1572962. JD064970 - Sequence 45994 from Patent EP1572962. JD269882 - Sequence 250906 from Patent EP1572962. JD305185 - Sequence 286209 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: A0A8V8TNW9, U86453, uc316bvp.1 UCSC ID: ENST00000698709.1 RefSeq Accession: NM_005026
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.