Human Gene ACE2 (ENST00000678046.1) from GENCODE V43
  Description: angiotensin I converting enzyme 2 (from HGNC ACE2)
RefSeq Summary (NM_001371415): The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2 (COVID-19 virus). [provided by RefSeq, Mar 2020].
Gencode Transcript: ENST00000678046.1
Gencode Gene: ENSG00000130234.13
Transcript (Including UTRs)
   Position: hg38 chrX:15,550,715-15,600,960 Size: 50,246 Total Exon Count: 18 Strand: -
Coding Region
   Position: hg38 chrX:15,551,073-15,600,911 Size: 49,839 Coding Exon Count: 18 

Page IndexSequence and LinksPrimersMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Data last updated at UCSC: 2023-02-17 22:02:02

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrX:15,550,715-15,600,960)mRNA (may differ from genome)Protein (771 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  MalaCards Disease Associations
  MalaCards Gene Search: ACE2
Diseases sorted by gene-association score: severe acute respiratory syndrome (28), neurogenic hypertension (18), hartnup disorder (14), tetanus neonatorum (9), internal hemorrhoid (9), intracranial aneurysm (8), posterior urethral valves (6), hypertension, essential (2), myocardial infarction (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 33.78 RPKM in Small Intestine - Terminal Ileum
Total median expression: 90.25 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -9.4049-0.192 Picture PostScript Text
3' UTR -85.60358-0.239 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Descriptions from all associated GenBank mRNAs
  AF291820 - Homo sapiens ACE-related carboxypeptidase ACE2 mRNA, complete cds.
BC048094 - Homo sapiens angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, mRNA (cDNA clone MGC:57146 IMAGE:5297380), complete cds.
BC048144 - Homo sapiens angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, mRNA (cDNA clone IMAGE:5297522).
AF241254 - Homo sapiens angiotensin converting enzyme-like protein mRNA, complete cds.
AB193260 - Homo sapiens ace2 mRNA for angiotensin-converting enzyme 2, complete cds, tissue_type: testis.
AB193259 - Homo sapiens ace2 mRNA for angiotensin-converting enzyme 2, complete cds, tissue_type: lung.
BC059378 - Homo sapiens cDNA clone IMAGE:5296531, partial cds.
BC039902 - Homo sapiens angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, mRNA (cDNA clone MGC:47598 IMAGE:5243048), complete cds.
AL110224 - Homo sapiens mRNA; cDNA DKFZp434A014 (from clone DKFZp434A014); partial cds.
BC032938 - Homo sapiens cDNA clone IMAGE:4830668, containing frame-shift errors.
AY358714 - Homo sapiens clone DNA79302 ACE2 (UNQ868) mRNA, complete cds.
AB046569 - Homo sapiens ace2 mRNA, complete cds.
AY623811 - Homo sapiens angiotensin converting enzyme 2 mRNA, complete cds.
GQ262784 - Homo sapiens angiotensin I converting enzyme 2 mRNA, complete cds.
AK315144 - Homo sapiens cDNA, FLJ96113, highly similar to Homo sapiens angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (ACE2), mRNA.
AB591025 - Synthetic construct DNA, clone: pFN21AE2097, Homo sapiens ACE2 gene for angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, without stop codon, in Flexi system.
KM576721 - Homo sapiens clone TMEM27-ACE2_T4-A2middle mRNA sequence.
KM576722 - Homo sapiens clone TMEM27-ACE2_T4-A2 mRNA sequence.
KM576723 - Homo sapiens clone TMEM27-ACE2_T5-A2middle mRNA sequence.
KM576724 - Homo sapiens clone TMEM27-ACE2_T5-A2 mRNA sequence.
DQ601838 - Homo sapiens piRNA piR-39904, complete sequence.
AK026461 - Homo sapiens cDNA: FLJ22808 fis, clone KAIA2925.
MT505392 - Homo sapiens truncated angiotensin converting enzyme 2 (ACE2) mRNA, complete cds.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04614 - Renin-angiotensin system

BioCarta from NCI Cancer Genome Anatomy Project
h_ace2Pathway - Angiotensin-converting enzyme 2 regulates heart function

-  Other Names for This Gene
  Alternate Gene Symbols: A0A7I2V2E9, AB046569, uc288spv.1
UCSC ID: ENST00000678046.1
RefSeq Accession: NM_001371415
CCDS: CCDS14169.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.