Human Gene STAT6 (ENST00000553533.2) from GENCODE V44
Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt H0YJH6) RefSeq Summary (NM_003153): The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]. Gencode Transcript: ENST00000553533.2 Gencode Gene: ENSG00000166888.12 Transcript (Including UTRs) Position: hg38 chr12:57,095,478-57,111,433 Size: 15,956 Total Exon Count: 23 Strand: - Coding Region Position: hg38 chr12:57,096,572-57,108,278 Size: 11,707 Coding Exon Count: 22
ID:H0YJH6_HUMAN DESCRIPTION: SubName: Full=Signal transducer and activator of transcription 6; Flags: Fragment; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00017 - SH2 domain PF02864 - STAT protein, DNA binding domain
ModBase Predicted Comparative 3D Structure on H0YJH6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
