Human Gene LRP1 (ENST00000553277.5) from GENCODE V44
Description: LDL receptor related protein 1 (from HGNC LRP1) RefSeq Summary (NM_002332): This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]. Gencode Transcript: ENST00000553277.5 Gencode Gene: ENSG00000123384.14 Transcript (Including UTRs) Position: hg38 chr12:57,128,493-57,150,059 Size: 21,567 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr12:57,128,965-57,149,729 Size: 20,765 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF07645 - Calcium-binding EGF domain PF00057 - Low-density lipoprotein receptor domain class A
ModBase Predicted Comparative 3D Structure on Q7Z7K9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.