Human Gene STAT6 (ENST00000537215.6) from GENCODE V44
Description: Homo sapiens signal transducer and activator of transcription 6 (STAT6), transcript variant 4, mRNA. (from RefSeq NM_001178080) RefSeq Summary (NM_001178080): The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]. Gencode Transcript: ENST00000537215.6 Gencode Gene: ENSG00000166888.12 Transcript (Including UTRs) Position: hg38 chr12:57,096,345-57,111,359 Size: 15,015 Total Exon Count: 21 Strand: - Coding Region Position: hg38 chr12:57,096,572-57,107,239 Size: 10,668 Coding Exon Count: 19
ID:STAT6_HUMAN DESCRIPTION: RecName: Full=Signal transducer and activator of transcription 6; AltName: Full=IL-4 Stat; FUNCTION: Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling. SUBUNIT: Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif. INTERACTION: Self; NbExp=2; IntAct=EBI-1186478, EBI-1186478; Q9UHD2:TBK1; NbExp=7; IntAct=EBI-1186478, EBI-356402; Q86WV6:TMEM173; NbExp=12; IntAct=EBI-1186478, EBI-2800345; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation. PTM: Tyrosine phosphorylated following stimulation by IL-4 and IL- 3 (By similarity). SIMILARITY: Belongs to the transcription factor STAT family. SIMILARITY: Contains 1 SH2 domain. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/stat6/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P42226
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0019903 protein phosphatase binding GO:0042802 identical protein binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0002296 T-helper 1 cell lineage commitment GO:0002829 negative regulation of type 2 immune response GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0007165 signal transduction GO:0019221 cytokine-mediated signaling pathway GO:0032481 positive regulation of type I interferon production GO:0033598 mammary gland epithelial cell proliferation GO:0034097 response to cytokine GO:0035771 interleukin-4-mediated signaling pathway GO:0042127 regulation of cell proliferation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048295 positive regulation of isotype switching to IgE isotypes GO:0060443 mammary gland morphogenesis GO:0070301 cellular response to hydrogen peroxide GO:1902170 cellular response to reactive nitrogen species