Human Gene CLCN5 (ENST00000482218.2) from GENCODE V44
Description: Homo sapiens chloride voltage-gated channel 5 (CLCN5), transcript variant 5, mRNA. (from RefSeq NM_001272102) RefSeq Summary (NM_001272102): This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]. Gencode Transcript: ENST00000482218.2 Gencode Gene: ENSG00000171365.17 Transcript (Including UTRs) Position: hg38 chrX:49,923,404-50,042,541 Size: 119,138 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chrX:49,925,299-50,042,494 Size: 117,196 Coding Exon Count: 2
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK092049 - Homo sapiens cDNA FLJ34730 fis, clone MESAN2006580, highly similar to Chloride channel protein 5. AK056560 - Homo sapiens cDNA FLJ31998 fis, clone NT2RP7009322, highly similar to CHLORIDE CHANNEL PROTEIN 5.