Human Gene TAC3 (ENST00000458521.7) from GENCODE V44
  Description: Homo sapiens tachykinin precursor 3 (TAC3), transcript variant 1, mRNA. (from RefSeq NM_013251)
RefSeq Summary (NM_013251): This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016].
Gencode Transcript: ENST00000458521.7
Gencode Gene: ENSG00000166863.13
Transcript (Including UTRs)
   Position: hg38 chr12:57,010,000-57,016,529 Size: 6,530 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg38 chr12:57,012,379-57,015,797 Size: 3,419 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesGeneReviewsMethods
Data last updated at UCSC: 2023-08-18 09:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr12:57,010,000-57,016,529)mRNA (may differ from genome)Protein (121 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Tachykinin-3; AltName: Full=ZNEUROK1; Contains: RecName: Full=Neurokinin-B; Short=NKB; AltName: Full=Neuromedin-K; Flags: Precursor;
FUNCTION: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity).
DEVELOPMENTAL STAGE: In pregnancy, the expression of NKB is confined to the outer syncytiotrophoblast of the placenta, significant concentrations of NKB can be detected in plasma as early as week 9, and plasma concentrations of NKB are grossly elevated in pregnancy-induced hypertension and pre-eclampsia.
SIMILARITY: Belongs to the tachykinin family.

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  MalaCards Disease Associations
  MalaCards Gene Search: TAC3
Diseases sorted by gene-association score: hypogonadotropic hypogonadism 10 with or without anosmia* (1230), tac3-related isolated gonadotropin-releasing hormone deficiency* (500), normosmic congenital hypogonadotropic hypogonadism* (165), eclampsia (29), hypogonadotropic hypogonadism (26), pre-eclampsia (26), hypogonadism (21), retinitis pigmentosa 67 (10), idiopathic central precocious puberty (7), preeclampsia/eclampsia 1 (4), kallmann syndrome (3)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.68 RPKM in Brain - Anterior cingulate cortex (BA24)
Total median expression: 70.46 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -43.90148-0.297 Picture PostScript Text
3' UTR -55.50290-0.191 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003635 - Neurokinin
IPR013055 - Tachy_Neuro_lke_CS

Pfam Domains:
PF03823 - Neurokinin B

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1P9F - NMR

ModBase Predicted Comparative 3D Structure on Q9UHF0
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0031836 neuromedin K receptor binding
GO:0031837 substance K receptor binding

Biological Process:
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007217 tachykinin receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007565 female pregnancy
GO:1902093 positive regulation of flagellated sperm motility

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space

-  Descriptions from all associated GenBank mRNAs
  KJ892241 - Synthetic construct Homo sapiens clone ccsbBroadEn_01635 TAC3 gene, encodes complete protein.
KR711156 - Synthetic construct Homo sapiens clone CCSBHm_00020862 TAC3 (TAC3) mRNA, encodes complete protein.
AX147032 - Sequence 3 from Patent WO0136979.
AF216586 - Homo sapiens neurokinin B mRNA, complete cds.
AX810703 - Sequence 27 from Patent EP1333092.
AY358679 - Homo sapiens clone DNA59849 TAC3 (UNQ585) mRNA, complete cds.
BC032145 - Homo sapiens tachykinin 3, mRNA (cDNA clone MGC:29520 IMAGE:4897300), complete cds.
AF186112 - Homo sapiens neurokinin B-like protein ZNEUROK1 (ZNEUROK1) mRNA, complete cds.
AF537113 - Homo sapiens alpha tachykinin 3 precursor variant 1 (TAC3) mRNA, complete cds.
AF537114 - Homo sapiens alpha tachykinin 3 precursor variant 2 (TAC3) mRNA, complete cds.
AF537115 - Homo sapiens alpha tachykinin 3 precursor variant 3 (TAC3) mRNA, complete cds.
AF537116 - Homo sapiens beta tachykinin 3 precursor variant 1 (TAC3) mRNA, complete cds.
AF537117 - Homo sapiens beta tachykinin 3 precursor variant 2 (TAC3) mRNA, complete cds.
AF537118 - Homo sapiens beta tachykinin 3 precursor variant 3 (TAC3) mRNA, complete cds.
AF537119 - Homo sapiens gamma tachykinin 3 precursor variant 1 (TAC3) mRNA, complete cds.
AF537120 - Homo sapiens gamma tachykinin 3 precursor variant 2 (TAC3) mRNA, complete cds.
AF537121 - Homo sapiens gamma tachykinin 3 precursor variant 3 (TAC3) mRNA, complete cds.
AX810719 - Sequence 43 from Patent EP1333092.
AF136174 - Homo sapiens preprotachykinin B mRNA, complete cds.
JD368637 - Sequence 349661 from Patent EP1572962.
JD242559 - Sequence 223583 from Patent EP1572962.
JD349437 - Sequence 330461 from Patent EP1572962.
DQ892259 - Synthetic construct clone IMAGE:100004889; FLH184655.01X; RZPDo839A06146D tachykinin 3 (neuromedin K, neurokinin beta) (TAC3) gene, encodes complete protein.
DQ895461 - Synthetic construct Homo sapiens clone IMAGE:100009921; FLH184651.01L; RZPDo839A06145D tachykinin 3 (neuromedin K, neurokinin beta) (TAC3) gene, encodes complete protein.
AB590435 - Synthetic construct DNA, clone: pFN21AE2161, Homo sapiens TAC3 gene for tachykinin 3, without stop codon, in Flexi system.
CR457193 - Homo sapiens full open reading frame cDNA clone RZPDo834H048D for gene TAC3, tachykinin 3 (neuromedin K, neurokinin beta); complete cds, incl. stopcodon.
JD445850 - Sequence 426874 from Patent EP1572962.
JD364940 - Sequence 345964 from Patent EP1572962.
JD372970 - Sequence 353994 from Patent EP1572962.
JD259428 - Sequence 240452 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04080 - Neuroactive ligand-receptor interaction

Reactome (by CSHL, EBI, and GO)

Protein Q9UHF0 (Reactome details) participates in the following event(s):

R-HSA-383373 Tachykinin receptor 3 (NK3) binds to neurokinin B
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-380095 Tachykinin receptors bind tachykinins
R-HSA-416476 G alpha (q) signalling events
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000458521.1, ENST00000458521.2, ENST00000458521.3, ENST00000458521.4, ENST00000458521.5, ENST00000458521.6, NKNB, NM_013251, Q6IAG2, Q71BC6, Q71BC9, Q9UHF0, TKNK_HUMAN, uc001smp.1, uc001smp.2, uc001smp.3, uc001smp.4, uc001smp.5, UNQ585/PRO1155
UCSC ID: ENST00000458521.7
RefSeq Accession: NM_013251
Protein: Q9UHF0 (aka TKNK_HUMAN)
CCDS: CCDS8928.1

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene TAC3:
kms (Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.