Human Gene STAT6 (ENST00000454075.7) from GENCODE V44
Description: Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling. (from UniProt P42226) RefSeq Summary (NM_001178078): The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]. Gencode Transcript: ENST00000454075.7 Gencode Gene: ENSG00000166888.12 Transcript (Including UTRs) Position: hg38 chr12:57,096,365-57,111,374 Size: 15,010 Total Exon Count: 22 Strand: - Coding Region Position: hg38 chr12:57,096,572-57,108,278 Size: 11,707 Coding Exon Count: 21
ID:STAT6_HUMAN DESCRIPTION: RecName: Full=Signal transducer and activator of transcription 6; AltName: Full=IL-4 Stat; FUNCTION: Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling. SUBUNIT: Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif. INTERACTION: Self; NbExp=2; IntAct=EBI-1186478, EBI-1186478; Q9UHD2:TBK1; NbExp=7; IntAct=EBI-1186478, EBI-356402; Q86WV6:TMEM173; NbExp=12; IntAct=EBI-1186478, EBI-2800345; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation. PTM: Tyrosine phosphorylated following stimulation by IL-4 and IL- 3 (By similarity). SIMILARITY: Belongs to the transcription factor STAT family. SIMILARITY: Contains 1 SH2 domain. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/stat6/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P42226
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0019903 protein phosphatase binding GO:0042802 identical protein binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0002296 T-helper 1 cell lineage commitment GO:0002829 negative regulation of type 2 immune response GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0007165 signal transduction GO:0019221 cytokine-mediated signaling pathway GO:0032481 positive regulation of type I interferon production GO:0033598 mammary gland epithelial cell proliferation GO:0034097 response to cytokine GO:0035771 interleukin-4-mediated signaling pathway GO:0042127 regulation of cell proliferation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048295 positive regulation of isotype switching to IgE isotypes GO:0060443 mammary gland morphogenesis GO:0070301 cellular response to hydrogen peroxide GO:1902170 cellular response to reactive nitrogen species