Human Gene TAC3 (ENST00000415231.1) from GENCODE V44
Description: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). (from UniProt Q9UHF0) RefSeq Summary (NM_013251): This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]. Gencode Transcript: ENST00000415231.1 Gencode Gene: ENSG00000166863.13 Transcript (Including UTRs) Position: hg38 chr12:57,012,378-57,028,883 Size: 16,506 Total Exon Count: 7 Strand: - Coding Region Position: hg38 chr12:57,012,379-57,015,797 Size: 3,419 Coding Exon Count: 5
ID:TKNK_HUMAN DESCRIPTION: RecName: Full=Tachykinin-3; AltName: Full=ZNEUROK1; Contains: RecName: Full=Neurokinin-B; Short=NKB; AltName: Full=Neuromedin-K; Flags: Precursor; FUNCTION: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). SUBCELLULAR LOCATION: Secreted. DEVELOPMENTAL STAGE: In pregnancy, the expression of NKB is confined to the outer syncytiotrophoblast of the placenta, significant concentrations of NKB can be detected in plasma as early as week 9, and plasma concentrations of NKB are grossly elevated in pregnancy-induced hypertension and pre-eclampsia. SIMILARITY: Belongs to the tachykinin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UHF0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.