ID:RDH16_HUMAN DESCRIPTION: RecName: Full=Retinol dehydrogenase 16; EC=1.1.-.-; AltName: Full=Microsomal NAD(+)-dependent retinol dehydrogenase 4; Short=RoDH-4; AltName: Full=Sterol/retinol dehydrogenase; FUNCTION: Oxidoreductase with a preference for NAD. Oxidizes all- trans-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol. Oxidizes 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction. ENZYME REGULATION: Inhibited by citral, perillyl alcohol, geraniol, farnesol and geranyl geraniol. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.14 uM for androsterone; KM=0.22 uM for androstanediol; KM=0.80 uM for dihydrotestosterone; KM=0.13 uM for NAD; KM=190 uM for NADP; SUBCELLULAR LOCATION: Microsome membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein (Potential). TISSUE SPECIFICITY: Highly expressed in adult liver (at protein level). Detected in endometrium, liver and foreskin. Detected in the spineous layers of adult skin, and at lower levels in basal and granular skin layers. Detected in fetal liver and lung. INDUCTION: Transiently up-regulated by retinoic acid. PTM: Not N-glycosylated. SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75452
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.