Human Gene NXPH4 (ENST00000349394.6) from GENCODE V44
  Description: Homo sapiens neurexophilin 4 (NXPH4), mRNA. (from RefSeq NM_007224)
Gencode Transcript: ENST00000349394.6
Gencode Gene: ENSG00000182379.10
Transcript (Including UTRs)
   Position: hg38 chr12:57,216,794-57,226,449 Size: 9,656 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg38 chr12:57,216,970-57,225,747 Size: 8,778 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 09:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr12:57,216,794-57,226,449)mRNA (may differ from genome)Protein (308 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Neurexophilin-4; Flags: Precursor;
FUNCTION: May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors (Potential).
SUBCELLULAR LOCATION: Secreted (Potential).
TISSUE SPECIFICITY: Expressed in brain, spleen, and testis.
PTM: May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells (By similarity).
SIMILARITY: Belongs to the neurexophilin family.

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.11 RPKM in Brain - Cerebellum
Total median expression: 67.00 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -61.90176-0.352 Picture PostScript Text
3' UTR -230.40702-0.328 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010450 - Neurexophilin

ModBase Predicted Comparative 3D Structure on O95158
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0005102 receptor binding

Biological Process:
GO:0007218 neuropeptide signaling pathway

Cellular Component:
GO:0005575 cellular_component
GO:0005576 extracellular region

-  Descriptions from all associated GenBank mRNAs
  LF208939 - JP 2014500723-A/16442: Polycomb-Associated Non-Coding RNAs.
MA444516 - JP 2018138019-A/16442: Polycomb-Associated Non-Coding RNAs.
LF212365 - JP 2014500723-A/19868: Polycomb-Associated Non-Coding RNAs.
MA447942 - JP 2018138019-A/19868: Polycomb-Associated Non-Coding RNAs.
AY358614 - Homo sapiens clone DNA83509 NXPH4 (UNQ1928) mRNA, complete cds.
BC036679 - Homo sapiens neurexophilin 4, mRNA (cDNA clone MGC:33909 IMAGE:5264190), complete cds.
AK094231 - Homo sapiens cDNA FLJ36912 fis, clone BRACE2003847, highly similar to Rattus norvegicus neurexophilin 4 (Nph4) mRNA.
AK290949 - Homo sapiens cDNA FLJ76167 complete cds, highly similar to Homo sapiens neurexophilin 4 (NXPH4), mRNA.
JD464407 - Sequence 445431 from Patent EP1572962.
BC053581 - Homo sapiens neurexophilin 4, mRNA (cDNA clone MGC:61782 IMAGE:5174266), complete cds.
CU690992 - Synthetic construct Homo sapiens gateway clone IMAGE:100021703 5' read NXPH4 mRNA.
HQ448073 - Synthetic construct Homo sapiens clone IMAGE:100071453; CCSB011874_01 neurexophilin 4 (NXPH4) gene, encodes complete protein.
KJ905416 - Synthetic construct Homo sapiens clone ccsbBroadEn_14991 NXPH4 gene, encodes complete protein.
AF043469 - Homo sapiens neurexophilin 4 (NPH4) mRNA, partial cds.
JD276971 - Sequence 257995 from Patent EP1572962.
JD554645 - Sequence 535669 from Patent EP1572962.
JD127246 - Sequence 108270 from Patent EP1572962.
JD124548 - Sequence 105572 from Patent EP1572962.
JD462158 - Sequence 443182 from Patent EP1572962.
JD552199 - Sequence 533223 from Patent EP1572962.
JD041629 - Sequence 22653 from Patent EP1572962.
JD138647 - Sequence 119671 from Patent EP1572962.
JD337942 - Sequence 318966 from Patent EP1572962.
JD392125 - Sequence 373149 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K4I4, ENST00000349394.1, ENST00000349394.2, ENST00000349394.3, ENST00000349394.4, ENST00000349394.5, NM_007224, NPH4, NXPH4_HUMAN, O95158, Q7Z6L3, Q8N462, uc010srf.1, uc010srf.2, uc010srf.3, UNQ1928/PRO4403
UCSC ID: ENST00000349394.6
RefSeq Accession: NM_007224
Protein: O95158 (aka NXPH4_HUMAN or NXP4_HUMAN)
CCDS: CCDS8933.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.