Human Gene NAB2 (ENST00000342556.6) from GENCODE V44
Description: Homo sapiens NGFI-A binding protein 2 (NAB2), transcript variant 2, mRNA. (from RefSeq NM_001330305) RefSeq Summary (NM_001330305): This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000342556.6 Gencode Gene: ENSG00000166886.13 Transcript (Including UTRs) Position: hg38 chr12:57,089,094-57,095,475 Size: 6,382 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr12:57,089,272-57,094,721 Size: 5,450 Coding Exon Count: 6
ID:NAB2_HUMAN DESCRIPTION: RecName: Full=NGFI-A-binding protein 2; AltName: Full=EGR-1-binding protein 2; AltName: Full=Melanoma-associated delayed early response protein; Short=Protein MADER; FUNCTION: Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). SUBUNIT: Homomultimers may associate with EGR1 bound to DNA (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). Note=Isoform 2 is not localized to the nucleus (By similarity). TISSUE SPECIFICITY: Widely expressed at low levels. Highly expressed in melanoma cell lines. INDUCTION: By serum and phorbol myristate acetate (PMA) stimulation. DOMAIN: The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization. DOMAIN: The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression. PTM: Sumoylation by EGR2 represses EGR2 transcriptional activity in hindbrain. SIMILARITY: Belongs to the NAB family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF04904 - NAB conserved region 1 (NCD1) PF04905 - NAB conserved region 2 (NCD2)
ModBase Predicted Comparative 3D Structure on Q15742
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.