Human Gene BMX (ENST00000342014.6) from GENCODE V39
Description: Homo sapiens BMX non-receptor tyrosine kinase (BMX), transcript variant 2, mRNA. (from RefSeq NM_001721) RefSeq Summary (NM_001721): This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]. Gencode Transcript: ENST00000342014.6 Gencode Gene: ENSG00000102010.15 Transcript (Including UTRs) Position: hg38 chrX:15,507,318-15,556,517 Size: 49,200 Total Exon Count: 19 Strand: + Coding Region Position: hg38 chrX:15,508,354-15,556,147 Size: 47,794 Coding Exon Count: 18
ID:BMX_HUMAN DESCRIPTION: RecName: Full=Cytoplasmic tyrosine-protein kinase BMX; EC=220.127.116.11; AltName: Full=Bone marrow tyrosine kinase gene in chromosome X protein; AltName: Full=Epithelial and endothelial tyrosine kinase; Short=ETK; AltName: Full=NTK38; FUNCTION: Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. COFACTOR: Binds 1 zinc ion per subunit (By similarity). ENZYME REGULATION: TEK and vascular endothelial growth factor receptor 1 (FLT1) stimulate BMX tyrosine kinase activity (By similarity). Activated by integrins through the mediation of PTK2/FAK1. Activated by TNF through the mediation of TNFRSF1B. SUBUNIT: Interacts with BCAR1, CAV1, MYD88, PTK2/FAK1, RUFY1, RUFY2, STAT3, TIRAP and TNFRSF1B. INTERACTION: P11309:PIM1; NbExp=8; IntAct=EBI-696657, EBI-696621; SUBCELLULAR LOCATION: Cytoplasm. Note=Localizes to the edges of spreading cells when complexed with BCAR1. TISSUE SPECIFICITY: Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines. INDUCTION: Activated by IL6/interleukin-6 through phosphatidylinositol 3-kinase (PI3-kinase) pathway. It is likely that activation occurs through binding of phosphoinositides to the PH domain. DOMAIN: SH2 domain mediates interaction with RUFY1. PTM: Phosphorylated in response to protein I/II and to LPS. Phosphorylation at Tyr-566 by SRC and by autocatalysis leads to activation and is required for STAT3 phosphorylation by BMX. SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. SIMILARITY: Contains 1 Btk-type zinc finger. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 protein kinase domain. SIMILARITY: Contains 1 SH2 domain. SEQUENCE CAUTION: Sequence=AAC08966.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P51813
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.