Human Gene LRRFIP2 (ENST00000336686.9) from GENCODE V44
Description: Homo sapiens LRR binding FLII interacting protein 2 (LRRFIP2), transcript variant 1, mRNA. (from RefSeq NM_006309) RefSeq Summary (NM_006309): The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]. Gencode Transcript: ENST00000336686.9 Gencode Gene: ENSG00000093167.18 Transcript (Including UTRs) Position: hg38 chr3:37,052,626-37,174,582 Size: 121,957 Total Exon Count: 28 Strand: - Coding Region Position: hg38 chr3:37,053,851-37,148,983 Size: 95,133 Coding Exon Count: 27
ID:LRRF2_HUMAN DESCRIPTION: RecName: Full=Leucine-rich repeat flightless-interacting protein 2; Short=LRR FLII-interacting protein 2; FUNCTION: May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta- catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. SUBUNIT: Interacts (via N-terminus) with DVL3. Interacts with FLII. Weakly interacts with MYD88 in resting cells. Following LPS- stimulation, the interaction with MYD88 is rapidly enhanced; the complex gradually dissociates to basal levels after 6 hours of stimulation. Interaction with MYD88 is regulated by LPS-induced phosphorylation at Ser-202. In the presence of LPS, competes with FLII for MYD88-binding. INTERACTION: Q92997:DVL3; NbExp=2; IntAct=EBI-1023718, EBI-739789; TISSUE SPECIFICITY: Widely expressed, with highest levels in heart and skeletal muscle. PTM: Ser-190 and Ser-202 are phosphorylated in response to LPS stimulation. Ser-202 phosphorylation regulates the LPS-induced interaction with MYD88. SIMILARITY: Belongs to the LRRFIP family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y608
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.