Human Gene GPR182 (ENST00000300098.3) from GENCODE V44
  Description: Homo sapiens G protein-coupled receptor 182 (GPR182), mRNA. (from RefSeq NM_007264)
RefSeq Summary (NM_007264): Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular function. This gene encodes a seven-transmembrane protein that belongs to the family 1 of G-protein coupled receptors. Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000300098.3
Gencode Gene: ENSG00000166856.3
Transcript (Including UTRs)
   Position: hg38 chr12:56,994,492-56,998,447 Size: 3,956 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg38 chr12:56,995,210-56,996,424 Size: 1,215 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 09:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr12:56,994,492-56,998,447)mRNA (may differ from genome)Protein (404 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=G-protein coupled receptor 182;
FUNCTION: Orphan receptor.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, immune system, adrenal gland and liver.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CAUTION: Was originally (PubMed:9367907) thought to be a receptor for adrenomedullin.

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.89 RPKM in Spleen
Total median expression: 21.34 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -58.30173-0.337 Picture PostScript Text
3' UTR -670.202023-0.331 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR001350 - G10D_rcpt
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

ModBase Predicted Comparative 3D Structure on O15218
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0035556 intracellular signal transduction

Cellular Component:
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  BC034761 - Homo sapiens G protein-coupled receptor 182, mRNA (cDNA clone MGC:34399 IMAGE:5185932), complete cds.
Y13583 - Homo sapiens mRNA for G-protein coupled receptor.
JD400453 - Sequence 381477 from Patent EP1572962.
JD192388 - Sequence 173412 from Patent EP1572962.
JD470641 - Sequence 451665 from Patent EP1572962.
JD493581 - Sequence 474605 from Patent EP1572962.
CU689962 - Synthetic construct Homo sapiens gateway clone IMAGE:100019252 5' read ADMR mRNA.
AB464542 - Synthetic construct DNA, clone: pF1KB8823, Homo sapiens ADMR gene for G protein-coupled receptor 182, without stop codon, in Flexi system.
DQ890853 - Synthetic construct clone IMAGE:100003483; FLH166480.01X; RZPDo839H0486D adrenomedullin receptor (ADMR) gene, encodes complete protein.
DQ896806 - Synthetic construct Homo sapiens clone IMAGE:100011266; FLH166476.01L; RZPDo839H0485D adrenomedullin receptor (ADMR) gene, encodes complete protein.
KJ893276 - Synthetic construct Homo sapiens clone ccsbBroadEn_02670 GPR182 gene, encodes complete protein.
AF529371 - Homo sapiens HBcAg-binding protein (HBCBP) mRNA, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: ADMR, ENST00000300098.1, ENST00000300098.2, GP182_HUMAN, NM_007264, O15218, uc001smk.1, uc001smk.2, uc001smk.3, uc001smk.4, uc001smk.5
UCSC ID: ENST00000300098.3
RefSeq Accession: NM_007264
Protein: O15218 (aka GP182_HUMAN)
CCDS: CCDS8927.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.