Human Gene GPR182 (ENST00000300098.3) from GENCODE V44
Description: Homo sapiens G protein-coupled receptor 182 (GPR182), mRNA. (from RefSeq NM_007264) RefSeq Summary (NM_007264): Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular function. This gene encodes a seven-transmembrane protein that belongs to the family 1 of G-protein coupled receptors. Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000300098.3 Gencode Gene: ENSG00000166856.3 Transcript (Including UTRs) Position: hg38 chr12:56,994,492-56,998,447 Size: 3,956 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chr12:56,995,210-56,996,424 Size: 1,215 Coding Exon Count: 1
ID:GP182_HUMAN DESCRIPTION: RecName: Full=G-protein coupled receptor 182; FUNCTION: Orphan receptor. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, immune system, adrenal gland and liver. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CAUTION: Was originally (PubMed:9367907) thought to be a receptor for adrenomedullin.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O15218
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
