ID:ADAD1_MOUSE DESCRIPTION: RecName: Full=Adenosine deaminase domain-containing protein 1; AltName: Full=Testis nuclear RNA-binding protein; FUNCTION: Plays a role in spermatogenesis. Binds to RNA but not to DNA. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Testis-specific. Detected in round spermatid cells from stage II-XI (at protein level). Expressed in germ cells from mid-pachytene spermatocytes to mid-round spermatids. DISRUPTION PHENOTYPE: Mice exhibit spermatozoa retention in stage IX tubules and a reduction in the number of sperm in the epididymis, leading to a reduction in fertility. SIMILARITY: Belongs to the ADAD family. SIMILARITY: Contains 1 A to I editase domain. SIMILARITY: Contains 1 DRBM (double-stranded RNA-binding) domain. SEQUENCE CAUTION: Sequence=CAM18414.1; Type=Erroneous gene model prediction; Sequence=CAM28072.1; Type=Erroneous gene model prediction; Sequence=CAM28078.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5SUE7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
