Mouse Gene Esx1 (ENSMUST00000113066.8) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Nucleus (By similarity). (from UniProt A2AG22)
Gencode Transcript: ENSMUST00000113066.8
Gencode Gene: ENSMUSG00000023443.13
Transcript (Including UTRs)
   Position: mm10 chrX:137,115,397-137,120,171 Size: 4,775 Total Exon Count: 4 Strand: -
Coding Region
   Position: mm10 chrX:137,115,550-137,119,577 Size: 4,028 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrX:137,115,397-137,120,171)mRNA (may differ from genome)Protein (314 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=Extraembryonic spermatogenesis homeobox 1; SubName: Full=Protein Esx1;
SUBCELLULAR LOCATION: Nucleus (By similarity).

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -206.40594-0.347 Picture PostScript Text
3' UTR -23.70153-0.155 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017970 - Homeobox_CS
IPR001356 - Homeodomain
IPR009057 - Homeodomain-like
IPR000047 - HTH_motif

Pfam Domains:
PF00046 - Homeobox domain

SCOP Domains:
46689 - Homeodomain-like

ModBase Predicted Comparative 3D Structure on A2AG22
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding

Biological Process:
GO:0001568 blood vessel development
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0060713 labyrinthine layer morphogenesis
GO:0060716 labyrinthine layer blood vessel development

Cellular Component:
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  AF017734 - Mus musculus paired-like homeobox (Epx) mRNA, transcript B, complete cds.
AF017735 - Mus musculus paired-like homeobox (Epx) mRNA, transcript A, complete cds.
AF004211 - Mus musculus paired-like homeodomain containing protein (Etx) mRNA, complete cds.
AF085715 - Mus musculus homeobox protein SPX1 mRNA, complete cds.
DQ059551 - Mus musculus ESX1 (esx1) mRNA, 5' UTR.

-  Other Names for This Gene
  Alternate Gene Symbols: A2AG22, A2AG22_MOUSE, AF004211, RP23-89D4.8-001, uc292qso.1
UCSC ID: uc292qso.1
RefSeq Accession: NM_007957
Protein: A2AG22

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.