Mouse Gene Lefty2 (ENSMUST00000085797.5) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus left-right determination factor 2 (Lefty2), mRNA. (from RefSeq NM_177099) RefSeq Summary (NM_177099): This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This protein is also important in self-renewal and differentiation of mouse embryonic stem cells. Mice lacking a functional copy of this gene exhibit defects in axial and left-right patterning. [provided by RefSeq, Aug 2016]. Gencode Transcript: ENSMUST00000085797.5 Gencode Gene: ENSMUSG00000066652.5 Transcript (Including UTRs) Position: mm10 chr1:180,893,108-180,899,103 Size: 5,996 Total Exon Count: 4 Strand: + Coding Region Position: mm10 chr1:180,893,184-180,897,813 Size: 4,630 Coding Exon Count: 4
ID:LFTY2_MOUSE DESCRIPTION: RecName: Full=Left-right determination factor 2; AltName: Full=Left-right determination factor B; AltName: Full=Protein lefty-2; AltName: Full=Protein lefty-B; Flags: Precursor; FUNCTION: Required for left-right asymmetry determination of organ systems in mammals. SUBCELLULAR LOCATION: Secreted. DEVELOPMENTAL STAGE: At the primitive streak stage (E7.0), expressed in the emerging mesoderm. By E8.0, expressed exclusively on the left side of developing embryos with expression predominantly in the lateral-plate mesoderm (LPM). Weak expression in the prospective floor plate (PFP). PTM: The processing of the protein may also occur at the second R- X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner. SIMILARITY: Belongs to the TGF-beta family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P57785
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Human
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Biological Process: GO:0007275 multicellular organism development GO:0010469 regulation of receptor activity GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0030509 BMP signaling pathway GO:0042981 regulation of apoptotic process GO:0043408 regulation of MAPK cascade GO:0048468 cell development GO:0060395 SMAD protein signal transduction
Cellular Component: GO:0005576 extracellular region GO:0005615 extracellular space
US Server
