The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q78ZW9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001085 RNA polymerase II transcription factor binding GO:0001102 RNA polymerase II activating transcription factor binding GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001570 vasculogenesis GO:0001756 somitogenesis GO:0001839 neural plate morphogenesis GO:0001843 neural tube closure GO:0003007 heart morphogenesis GO:0003257 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0007341 penetration of zona pellucida GO:0007498 mesoderm development GO:0007509 mesoderm migration involved in gastrulation GO:0008284 positive regulation of cell proliferation GO:0009653 anatomical structure morphogenesis GO:0009952 anterior/posterior pattern specification GO:0014028 notochord formation GO:0022414 reproductive process GO:0023019 signal transduction involved in regulation of gene expression GO:0030509 BMP signaling pathway GO:0030903 notochord development GO:0036342 post-anal tail morphogenesis GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048706 embryonic skeletal system development GO:0060070 canonical Wnt signaling pathway GO:0060349 bone morphogenesis GO:0060395 SMAD protein signal transduction GO:0061371 determination of heart left/right asymmetry GO:0071300 cellular response to retinoic acid
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