Mouse Gene Bmp4 (ENSMUST00000074077.11) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus bone morphogenetic protein 4 (Bmp4), transcript variant 1, mRNA. (from RefSeq NM_007554)
RefSeq Summary (NM_007554): This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Homozygous knockout mice die in utero, while a conditional knockout mouse exhibits defects in heart development. Transgenic mice overexpressing this gene in a neuron-specific manner exhibit a phenotype resembling the rare hereditary connective tissue disease, fibrodysplasia ossificans progressiva. [provided by RefSeq, Jul 2016].
Gencode Transcript: ENSMUST00000074077.11
Gencode Gene: ENSMUSG00000021835.15
Transcript (Including UTRs)
   Position: mm10 chr14:46,383,520-46,390,669 Size: 7,150 Total Exon Count: 4 Strand: -
Coding Region
   Position: mm10 chr14:46,383,859-46,386,087 Size: 2,229 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr14:46,383,520-46,390,669)mRNA (may differ from genome)Protein (408 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=Bone morphogenetic protein 4; SubName: Full=Bone morphogenetic protein 4, isoform CRA_a;
SIMILARITY: Belongs to the TGF-beta family.

-  Primer design for this transcript

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -179.00498-0.359 Picture PostScript Text
3' UTR -25.69339-0.076 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001839 - TGF-b_C
IPR001111 - TGF-b_N
IPR015615 - TGF-beta-rel
IPR017948 - TGFb_CS

Pfam Domains:
PF00019 - Transforming growth factor beta like domain
PF00688 - TGF-beta propeptide

SCOP Domains:
57501 - Cystine-knot cytokines

ModBase Predicted Comparative 3D Structure on Q3ULR1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005125 cytokine activity
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0039706 co-receptor binding
GO:0042056 chemoattractant activity
GO:0070700 BMP receptor binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000186 activation of MAPKK activity
GO:0001501 skeletal system development
GO:0001525 angiogenesis
GO:0001568 blood vessel development
GO:0001649 osteoblast differentiation
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001707 mesoderm formation
GO:0001759 organ induction
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0001843 neural tube closure
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001944 vasculature development
GO:0001958 endochondral ossification
GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0002062 chondrocyte differentiation
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002320 lymphoid progenitor cell differentiation
GO:0003014 renal system process
GO:0003130 BMP signaling pathway involved in heart induction
GO:0003139 secondary heart field specification
GO:0003148 outflow tract septum morphogenesis
GO:0003149 membranous septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003180 aortic valve morphogenesis
GO:0003184 pulmonary valve morphogenesis
GO:0003197 endocardial cushion development
GO:0003323 type B pancreatic cell development
GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0007182 common-partner SMAD protein phosphorylation
GO:0007224 smoothened signaling pathway
GO:0007281 germ cell development
GO:0007492 endoderm development
GO:0007500 mesodermal cell fate determination
GO:0007507 heart development
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009791 post-embryonic development
GO:0009888 tissue development
GO:0009948 anterior/posterior axis specification
GO:0010159 specification of animal organ position
GO:0010453 regulation of cell fate commitment
GO:0010468 regulation of gene expression
GO:0010469 regulation of receptor activity
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010942 positive regulation of cell death
GO:0021537 telencephalon development
GO:0021904 dorsal/ventral neural tube patterning
GO:0021978 telencephalon regionalization
GO:0021983 pituitary gland development
GO:0030218 erythrocyte differentiation
GO:0030224 monocyte differentiation
GO:0030225 macrophage differentiation
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0030335 positive regulation of cell migration
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0030900 forebrain development
GO:0032092 positive regulation of protein binding
GO:0032331 negative regulation of chondrocyte differentiation
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033085 negative regulation of T cell differentiation in thymus
GO:0033088 negative regulation of immature T cell proliferation in thymus
GO:0034504 protein localization to nucleus
GO:0035116 embryonic hindlimb morphogenesis
GO:0035990 tendon cell differentiation
GO:0035993 deltoid tuberosity development
GO:0042306 regulation of protein import into nucleus
GO:0042326 negative regulation of phosphorylation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042476 odontogenesis
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0042733 embryonic digit morphogenesis
GO:0043010 camera-type eye development
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043401 steroid hormone mediated signaling pathway
GO:0043407 negative regulation of MAP kinase activity
GO:0045165 cell fate commitment
GO:0045595 regulation of cell differentiation
GO:0045597 positive regulation of cell differentiation
GO:0045603 positive regulation of endothelial cell differentiation
GO:0045606 positive regulation of epidermal cell differentiation
GO:0045662 negative regulation of myoblast differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045778 positive regulation of ossification
GO:0045786 negative regulation of cell cycle
GO:0045839 negative regulation of mitotic nuclear division
GO:0045843 negative regulation of striated muscle tissue development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048286 lung alveolus development
GO:0048333 mesodermal cell differentiation
GO:0048392 intermediate mesodermal cell differentiation
GO:0048593 camera-type eye morphogenesis
GO:0048598 embryonic morphogenesis
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048663 neuron fate commitment
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048745 smooth muscle tissue development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050918 positive chemotaxis
GO:0051145 smooth muscle cell differentiation
GO:0051150 regulation of smooth muscle cell differentiation
GO:0055007 cardiac muscle cell differentiation
GO:0055020 positive regulation of cardiac muscle fiber development
GO:0060113 inner ear receptor cell differentiation
GO:0060197 cloacal septation
GO:0060235 lens induction in camera-type eye
GO:0060272 embryonic skeletal joint morphogenesis
GO:0060348 bone development
GO:0060363 cranial suture morphogenesis
GO:0060391 positive regulation of SMAD protein import into nucleus
GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation
GO:0060395 SMAD protein signal transduction
GO:0060425 lung morphogenesis
GO:0060429 epithelium development
GO:0060433 bronchus development
GO:0060438 trachea development
GO:0060440 trachea formation
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060442 branching involved in prostate gland morphogenesis
GO:0060449 bud elongation involved in lung branching
GO:0060502 epithelial cell proliferation involved in lung morphogenesis
GO:0060503 bud dilation involved in lung branching
GO:0060512 prostate gland morphogenesis
GO:0060548 negative regulation of cell death
GO:0060592 mammary gland formation
GO:0060684 epithelial-mesenchymal cell signaling
GO:0060686 negative regulation of prostatic bud formation
GO:0060687 regulation of branching involved in prostate gland morphogenesis
GO:0060688 regulation of morphogenesis of a branching structure
GO:0060976 coronary vasculature development
GO:0061035 regulation of cartilage development
GO:0061036 positive regulation of cartilage development
GO:0061047 positive regulation of branching involved in lung morphogenesis
GO:0061149 BMP signaling pathway involved in ureter morphogenesis
GO:0061151 BMP signaling pathway involved in renal system segmentation
GO:0061155 pulmonary artery endothelial tube morphogenesis
GO:0061312 BMP signaling pathway involved in heart development
GO:0061626 pharyngeal arch artery morphogenesis
GO:0070244 negative regulation of thymocyte apoptotic process
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071363 cellular response to growth factor stimulus
GO:0071773 cellular response to BMP stimulus
GO:0071893 BMP signaling pathway involved in nephric duct formation
GO:0072001 renal system development
GO:0072015 glomerular visceral epithelial cell development
GO:0072097 negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway
GO:0072101 specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
GO:0072104 glomerular capillary formation
GO:0072125 negative regulation of glomerular mesangial cell proliferation
GO:0072138 mesenchymal cell proliferation involved in ureteric bud development
GO:0072161 mesenchymal cell differentiation involved in kidney development
GO:0072192 ureter epithelial cell differentiation
GO:0072193 ureter smooth muscle cell differentiation
GO:0072198 mesenchymal cell proliferation involved in ureter development
GO:0072200 negative regulation of mesenchymal cell proliferation involved in ureter development
GO:0072205 metanephric collecting duct development
GO:0090184 positive regulation of kidney development
GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis
GO:0090194 negative regulation of glomerulus development
GO:1901964 positive regulation of cell proliferation involved in outflow tract morphogenesis
GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:1905312 positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:2000005 negative regulation of metanephric S-shaped body morphogenesis
GO:2000007 negative regulation of metanephric comma-shaped body morphogenesis
GO:2000137 negative regulation of cell proliferation involved in heart morphogenesis
GO:2001012 mesenchymal cell differentiation involved in renal system development
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space

-  Descriptions from all associated GenBank mRNAs
  AK145359 - Mus musculus 5 days embryo whole body cDNA, RIKEN full-length enriched library, clone:I0C0022P08 product:bone morphogenetic protein 4, full insert sequence.
E04737 - cDNA encoding mouse bone morphogenetic protein.
S65032 - Mus sp. bone morphogenetic protein-4 mRNA, complete cds.
BC052846 - Mus musculus bone morphogenetic protein 4, mRNA (cDNA clone MGC:60635 IMAGE:30054617), complete cds.
X56848 - M.musculus mRNA for bone morphogenetic protein 4 (BMP-4).
BC034053 - Mus musculus bone morphogenetic protein 4, mRNA (cDNA clone MGC:31017 IMAGE:4192158), complete cds.
BC013459 - Mus musculus bone morphogenetic protein 4, mRNA (cDNA clone MGC:18646 IMAGE:4219098), complete cds.
AK136527 - Mus musculus adult male cecum cDNA, RIKEN full-length enriched library, clone:9130025H09 product:bone morphogenetic protein 4, full insert sequence.
LF203199 - JP 2014500723-A/10702: Polycomb-Associated Non-Coding RNAs.
MA438776 - JP 2018138019-A/10702: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04060 - Cytokine-cytokine receptor interaction
mmu04340 - Hedgehog signaling pathway
mmu04350 - TGF-beta signaling pathway
mmu05200 - Pathways in cancer
mmu05217 - Basal cell carcinoma

-  Other Names for This Gene
  Alternate Gene Symbols: mCG_4634, NM_007554, Q3ULR1, Q3ULR1_MOUSE, RP23-87H19.2-001, uc007thd.1, uc007thd.2, uc007thd.3, uc007thd.4
UCSC ID: uc007thd.4
RefSeq Accession: NM_007554
Protein: Q3ULR1 CCDS: CCDS36897.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.