Mouse Gene Bmp4 (ENSMUST00000074077.11) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus bone morphogenetic protein 4 (Bmp4), transcript variant 1, mRNA. (from RefSeq NM_007554)
RefSeq Summary (NM_007554): This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Homozygous knockout mice die in utero, while a conditional knockout mouse exhibits defects in heart development. Transgenic mice overexpressing this gene in a neuron-specific manner exhibit a phenotype resembling the rare hereditary connective tissue disease, fibrodysplasia ossificans progressiva. [provided by RefSeq, Jul 2016].
Gencode Transcript: ENSMUST00000074077.11
Gencode Gene: ENSMUSG00000021835.15
Transcript (Including UTRs)
   Position: mm10 chr14:46,383,520-46,390,669 Size: 7,150 Total Exon Count: 4 Strand: -
Coding Region
   Position: mm10 chr14:46,383,859-46,386,087 Size: 2,229 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:46,383,520-46,390,669)mRNA (may differ from genome)Protein (408 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: Q3ULR1_MOUSE
DESCRIPTION: SubName: Full=Bone morphogenetic protein 4; SubName: Full=Bone morphogenetic protein 4, isoform CRA_a;
SIMILARITY: Belongs to the TGF-beta family.

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -179.00498-0.359 Picture PostScript Text
3' UTR -25.69339-0.076 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001839 - TGF-b_C
IPR001111 - TGF-b_N
IPR015615 - TGF-beta-rel
IPR017948 - TGFb_CS

Pfam Domains:
PF00019 - Transforming growth factor beta like domain
PF00688 - TGF-beta propeptide

SCOP Domains:
57501 - Cystine-knot cytokines

ModBase Predicted Comparative 3D Structure on Q3ULR1
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005125 cytokine activity
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0039706 co-receptor binding
GO:0042056 chemoattractant activity
GO:0070700 BMP receptor binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000186 activation of MAPKK activity
GO:0001501 skeletal system development
GO:0001525 angiogenesis
GO:0001568 blood vessel development
GO:0001649 osteoblast differentiation
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001707 mesoderm formation
GO:0001759 organ induction
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0001843 neural tube closure
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001944 vasculature development
GO:0001958 endochondral ossification
GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0002062 chondrocyte differentiation
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002320 lymphoid progenitor cell differentiation
GO:0003014 renal system process
GO:0003130 BMP signaling pathway involved in heart induction
GO:0003139 secondary heart field specification
GO:0003148 outflow tract septum morphogenesis
GO:0003149 membranous septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003180 aortic valve morphogenesis
GO:0003184 pulmonary valve morphogenesis
GO:0003197 endocardial cushion development
GO:0003323 type B pancreatic cell development
GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0007182 common-partner SMAD protein phosphorylation
GO:0007224 smoothened signaling pathway
GO:0007281 germ cell development
GO:0007492 endoderm development
GO:0007500 mesodermal cell fate determination
GO:0007507 heart development
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009791 post-embryonic development
GO:0009888 tissue development
GO:0009948 anterior/posterior axis specification
GO:0010159 specification of animal organ position
GO:0010453 regulation of cell fate commitment
GO:0010468 regulation of gene expression
GO:0010469 regulation of receptor activity
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010942 positive regulation of cell death
GO:0021537 telencephalon development
GO:0021904 dorsal/ventral neural tube patterning
GO:0021978 telencephalon regionalization
GO:0021983 pituitary gland development
GO:0030218 erythrocyte differentiation
GO:0030224 monocyte differentiation
GO:0030225 macrophage differentiation
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0030335 positive regulation of cell migration
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0030900 forebrain development
GO:0032092 positive regulation of protein binding
GO:0032331 negative regulation of chondrocyte differentiation
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033085 negative regulation of T cell differentiation in thymus
GO:0033088 negative regulation of immature T cell proliferation in thymus
GO:0034504 protein localization to nucleus
GO:0035116 embryonic hindlimb morphogenesis
GO:0035990 tendon cell differentiation
GO:0035993 deltoid tuberosity development
GO:0042306 regulation of protein import into nucleus
GO:0042326 negative regulation of phosphorylation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042476 odontogenesis
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0042733 embryonic digit morphogenesis
GO:0043010 camera-type eye development
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043401 steroid hormone mediated signaling pathway
GO:0043407 negative regulation of MAP kinase activity
GO:0045165 cell fate commitment
GO:0045595 regulation of cell differentiation
GO:0045597 positive regulation of cell differentiation
GO:0045603 positive regulation of endothelial cell differentiation
GO:0045606 positive regulation of epidermal cell differentiation
GO:0045662 negative regulation of myoblast differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045778 positive regulation of ossification
GO:0045786 negative regulation of cell cycle
GO:0045839 negative regulation of mitotic nuclear division
GO:0045843 negative regulation of striated muscle tissue development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048286 lung alveolus development
GO:0048333 mesodermal cell differentiation
GO:0048392 intermediate mesodermal cell differentiation
GO:0048593 camera-type eye morphogenesis
GO:0048598 embryonic morphogenesis
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048663 neuron fate commitment
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048745 smooth muscle tissue development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050918 positive chemotaxis
GO:0051145 smooth muscle cell differentiation
GO:0051150 regulation of smooth muscle cell differentiation
GO:0055007 cardiac muscle cell differentiation
GO:0055020 positive regulation of cardiac muscle fiber development
GO:0060113 inner ear receptor cell differentiation
GO:0060197 cloacal septation
GO:0060235 lens induction in camera-type eye
GO:0060272 embryonic skeletal joint morphogenesis
GO:0060348 bone development
GO:0060363 cranial suture morphogenesis
GO:0060391 positive regulation of SMAD protein import into nucleus
GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation
GO:0060395 SMAD protein signal transduction
GO:0060425 lung morphogenesis
GO:0060429 epithelium development
GO:0060433 bronchus development
GO:0060438 trachea development
GO:0060440 trachea formation
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060442 branching involved in prostate gland morphogenesis
GO:0060449 bud elongation involved in lung branching
GO:0060502 epithelial cell proliferation involved in lung morphogenesis
GO:0060503 bud dilation involved in lung branching
GO:0060512 prostate gland morphogenesis
GO:0060548 negative regulation of cell death
GO:0060592 mammary gland formation
GO:0060684 epithelial-mesenchymal cell signaling
GO:0060686 negative regulation of prostatic bud formation
GO:0060687 regulation of branching involved in prostate gland morphogenesis
GO:0060688 regulation of morphogenesis of a branching structure
GO:0060976 coronary vasculature development
GO:0061035 regulation of cartilage development
GO:0061036 positive regulation of cartilage development
GO:0061047 positive regulation of branching involved in lung morphogenesis
GO:0061149 BMP signaling pathway involved in ureter morphogenesis
GO:0061151 BMP signaling pathway involved in renal system segmentation
GO:0061155 pulmonary artery endothelial tube morphogenesis
GO:0061312 BMP signaling pathway involved in heart development
GO:0061626 pharyngeal arch artery morphogenesis
GO:0070244 negative regulation of thymocyte apoptotic process
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071363 cellular response to growth factor stimulus
GO:0071773 cellular response to BMP stimulus
GO:0071893 BMP signaling pathway involved in nephric duct formation
GO:0072001 renal system development
GO:0072015 glomerular visceral epithelial cell development
GO:0072097 negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway
GO:0072101 specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
GO:0072104 glomerular capillary formation
GO:0072125 negative regulation of glomerular mesangial cell proliferation
GO:0072138 mesenchymal cell proliferation involved in ureteric bud development
GO:0072161 mesenchymal cell differentiation involved in kidney development
GO:0072192 ureter epithelial cell differentiation
GO:0072193 ureter smooth muscle cell differentiation
GO:0072198 mesenchymal cell proliferation involved in ureter development
GO:0072200 negative regulation of mesenchymal cell proliferation involved in ureter development
GO:0072205 metanephric collecting duct development
GO:0090184 positive regulation of kidney development
GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis
GO:0090194 negative regulation of glomerulus development
GO:1901964 positive regulation of cell proliferation involved in outflow tract morphogenesis
GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:1905312 positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:2000005 negative regulation of metanephric S-shaped body morphogenesis
GO:2000007 negative regulation of metanephric comma-shaped body morphogenesis
GO:2000137 negative regulation of cell proliferation involved in heart morphogenesis
GO:2001012 mesenchymal cell differentiation involved in renal system development
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space


-  Descriptions from all associated GenBank mRNAs
  AK145359 - Mus musculus 5 days embryo whole body cDNA, RIKEN full-length enriched library, clone:I0C0022P08 product:bone morphogenetic protein 4, full insert sequence.
E04737 - cDNA encoding mouse bone morphogenetic protein.
S65032 - Mus sp. bone morphogenetic protein-4 mRNA, complete cds.
BC052846 - Mus musculus bone morphogenetic protein 4, mRNA (cDNA clone MGC:60635 IMAGE:30054617), complete cds.
X56848 - M.musculus mRNA for bone morphogenetic protein 4 (BMP-4).
BC034053 - Mus musculus bone morphogenetic protein 4, mRNA (cDNA clone MGC:31017 IMAGE:4192158), complete cds.
BC013459 - Mus musculus bone morphogenetic protein 4, mRNA (cDNA clone MGC:18646 IMAGE:4219098), complete cds.
AK136527 - Mus musculus adult male cecum cDNA, RIKEN full-length enriched library, clone:9130025H09 product:bone morphogenetic protein 4, full insert sequence.
LF203199 - JP 2014500723-A/10702: Polycomb-Associated Non-Coding RNAs.
MA438776 - JP 2018138019-A/10702: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04060 - Cytokine-cytokine receptor interaction
mmu04340 - Hedgehog signaling pathway
mmu04350 - TGF-beta signaling pathway
mmu05200 - Pathways in cancer
mmu05217 - Basal cell carcinoma

-  Other Names for This Gene
  Alternate Gene Symbols: mCG_4634, NM_007554, Q3ULR1, Q3ULR1_MOUSE, RP23-87H19.2-001, uc007thd.1, uc007thd.2, uc007thd.3, uc007thd.4
UCSC ID: uc007thd.4
RefSeq Accession: NM_007554
Protein: Q3ULR1 CCDS: CCDS36897.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.