Mouse Gene Tdgf1 (ENSMUST00000035075.12) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus teratocarcinoma-derived growth factor 1 (Tdgf1), mRNA. (from RefSeq NM_011562)
Gencode Transcript: ENSMUST00000035075.12
Gencode Gene: ENSMUSG00000032494.12
Transcript (Including UTRs)
   Position: mm10 chr9:110,939,603-110,946,158 Size: 6,556 Total Exon Count: 6 Strand: -
Coding Region
   Position: mm10 chr9:110,940,704-110,945,843 Size: 5,140 Coding Exon Count: 6 

Page IndexSequence and LinksPrimersCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr9:110,939,603-110,946,158)mRNA (may differ from genome)Protein (171 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -80.50315-0.256 Picture PostScript Text
3' UTR -301.601101-0.274 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017047 - Cripto_growth_factor
IPR019011 - Cryptic/Cripto_CFC-dom
IPR000742 - EG-like_dom
IPR013032 - EGF-like_CS

Pfam Domains:
PF09443 - Cripto_Frl-1_Cryptic (CFC)

SCOP Domains:
57196 - EGF/Laminin

ModBase Predicted Comparative 3D Structure on Q7TQ06
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005102 receptor binding
GO:0008083 growth factor activity

Biological Process:
GO:0000187 activation of MAPK activity
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0007507 heart development
GO:0008284 positive regulation of cell proliferation
GO:0009966 regulation of signal transduction
GO:0010469 regulation of receptor activity
GO:0010595 positive regulation of endothelial cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0030335 positive regulation of cell migration
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0043066 negative regulation of apoptotic process
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0071346 cellular response to interferon-gamma
GO:0071354 cellular response to interleukin-6
GO:0071356 cellular response to tumor necrosis factor
GO:0071364 cellular response to epidermal growth factor stimulus

Cellular Component:
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016324 apical plasma membrane
GO:0045121 membrane raft

-  Descriptions from all associated GenBank mRNAs
  M87321 - Mouse cripto gene mRNA, complete cds.
BC052646 - Mus musculus teratocarcinoma-derived growth factor 1, mRNA (cDNA clone MGC:60569 IMAGE:30029798), complete cds.
AK133730 - Mus musculus 6 days embryo whole body cDNA, RIKEN full-length enriched library, clone:5630400F13 product:teratocarcinoma-derived growth factor, full insert sequence.
AK163969 - Mus musculus ES cells cDNA, RIKEN full-length enriched library, clone:C330018M09 product:teratocarcinoma-derived growth factor, full insert sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_011562, Q7TQ06, Q7TQ06_MOUSE, uc009rvg.1, uc009rvg.2
UCSC ID: uc009rvg.2
RefSeq Accession: NM_011562
Protein: Q7TQ06 CCDS: CCDS40783.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.