Description: Homo sapiens VCP-interacting membrane protein (SELENOS), transcript variant 1, mRNA. RefSeq Summary (NM_203472): This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019). [provided by RefSeq, Jul 2017]. Transcript (Including UTRs) Position: hg19 chr15:101,811,214-101,817,700 Size: 6,487 Total Exon Count: 7 Strand: - Coding Region Position: hg19 chr15:101,812,976-101,817,622 Size: 4,647 Coding Exon Count: 6
ID:SELS_HUMAN DESCRIPTION: RecName: Full=Selenoprotein S; Short=SelS; AltName: Full=VCP-interacting membrane protein; FUNCTION: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination. SUBUNIT: Interacts with DERL1 and VCP, suggesting that it forms a membrane complex with DERL1 that serves as a receptor for VCP. INTERACTION: Q01853:Vcp (xeno); NbExp=4; IntAct=EBI-398970, EBI-80597; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Cytoplasm (By similarity). SIMILARITY: Belongs to the selenoprotein S family. SEQUENCE CAUTION: Sequence=AAF67483.1; Type=Frameshift; Positions=173; Sequence=AAK15708.1; Type=Erroneous termination; Positions=188; Note=Translated as Sec;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BQE4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus GO:0006111 regulation of gluconeogenesis GO:0006886 intracellular protein transport GO:0006983 ER overload response GO:0009749 response to glucose GO:0016567 protein ubiquitination GO:0030433 ER-associated ubiquitin-dependent protein catabolic process GO:0030968 endoplasmic reticulum unfolded protein response GO:0030970 retrograde protein transport, ER to cytosol GO:0032715 negative regulation of interleukin-6 production GO:0032720 negative regulation of tumor necrosis factor production GO:0032869 cellular response to insulin stimulus GO:0034599 cellular response to oxidative stress GO:0045184 establishment of protein localization GO:0045454 cell redox homeostasis GO:0045719 negative regulation of glycogen biosynthetic process GO:0046325 negative regulation of glucose import GO:0050728 negative regulation of inflammatory response GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process GO:0051775 response to redox state GO:0071222 cellular response to lipopolysaccharide GO:0080164 regulation of nitric oxide metabolic process GO:0098869 cellular oxidant detoxification GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:2000110 negative regulation of macrophage apoptotic process
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
