Description: Homo sapiens UDP-glucose 6-dehydrogenase (UGDH), transcript variant 1, mRNA. RefSeq Summary (NM_003359): The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]. Transcript (Including UTRs) Position: hg19 chr4:39,500,375-39,529,218 Size: 28,844 Total Exon Count: 12 Strand: - Coding Region Position: hg19 chr4:39,501,763-39,523,132 Size: 21,370 Coding Exon Count: 11
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60701
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003824 catalytic activity GO:0003979 UDP-glucose 6-dehydrogenase activity GO:0009055 electron carrier activity GO:0016491 oxidoreductase activity GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0051287 NAD binding
Biological Process: GO:0001702 gastrulation with mouth forming second GO:0006011 UDP-glucose metabolic process GO:0006024 glycosaminoglycan biosynthetic process GO:0006065 UDP-glucuronate biosynthetic process GO:0008152 metabolic process GO:0022900 electron transport chain GO:0055114 oxidation-reduction process
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
