ID:PP2BA_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; EC=3.1.3.16; AltName: Full=CAM-PRP catalytic subunit; AltName: Full=Calmodulin-dependent calcineurin A subunit alpha isoform; FUNCTION: Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1. CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate. COFACTOR: Binds 1 Fe(3+) ion per subunit. COFACTOR: Binds 1 zinc ion per subunit. SUBUNIT: Interacts with CHP1 and CHP2 (By similarity). Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with CRTC2, MYOZ1, MYOZ2 and MYOZ3. Interacts with DNM1L; the interaction dephosphorylates DNM1L and regulates its translocation to mitochondria. Interacts with CMYA5; this interaction represses calcineurin activity in muscle (By similarity). INTERACTION: P62993:GRB2; NbExp=2; IntAct=EBI-352922, EBI-401755; SUBCELLULAR LOCATION: Nucleus (By similarity). Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle (By similarity). SIMILARITY: Belongs to the PPP phosphatase family. PP-2B subfamily. WEB RESOURCE: Name=Wikipedia; Note=Calcineurin entry; URL="http://en.wikipedia.org/wiki/Calcineurin";
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): PPP3CA CDC HuGE Published Literature: PPP3CA Positive Disease Associations: Keratoconus Related Studies:
Keratoconus Xiaohui Li et al. Human molecular genetics 2012, A genome-wide association study identifies a potential novel gene locus for keratoconus, one of the commonest causes for corneal transplantation in developed countries., Human molecular genetics.
[PubMed 21979947]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q08209
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004721 phosphoprotein phosphatase activity GO:0004722 protein serine/threonine phosphatase activity GO:0004723 calcium-dependent protein serine/threonine phosphatase activity GO:0005509 calcium ion binding GO:0005515 protein binding GO:0005516 calmodulin binding GO:0008144 drug binding GO:0016018 cyclosporin A binding GO:0016787 hydrolase activity GO:0019899 enzyme binding GO:0033192 calmodulin-dependent protein phosphatase activity GO:0046872 metal ion binding GO:0046982 protein heterodimerization activity GO:0046983 protein dimerization activity
Biological Process: GO:0000082 G1/S transition of mitotic cell cycle GO:0001975 response to amphetamine GO:0006470 protein dephosphorylation GO:0006606 protein import into nucleus GO:0006816 calcium ion transport GO:0007223 Wnt signaling pathway, calcium modulating pathway GO:0010613 positive regulation of cardiac muscle hypertrophy GO:0010628 positive regulation of gene expression GO:0010629 negative regulation of gene expression GO:0014883 transition between fast and slow fiber GO:0014898 cardiac muscle hypertrophy in response to stress GO:0016311 dephosphorylation GO:0019722 calcium-mediated signaling GO:0033173 calcineurin-NFAT signaling cascade GO:0033555 multicellular organismal response to stress GO:0035562 negative regulation of chromatin binding GO:0035690 cellular response to drug GO:0038095 Fc-epsilon receptor signaling pathway GO:0042110 T cell activation GO:0045807 positive regulation of endocytosis GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046676 negative regulation of insulin secretion GO:0048741 skeletal muscle fiber development GO:0050774 negative regulation of dendrite morphogenesis GO:0050804 modulation of synaptic transmission GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051592 response to calcium ion GO:0060079 excitatory postsynaptic potential GO:0070886 positive regulation of calcineurin-NFAT signaling cascade GO:0071333 cellular response to glucose stimulus GO:1903244 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1905205 positive regulation of connective tissue replacement
BioCarta from NCI Cancer Genome Anatomy Project h_gpcrPathway - Signaling Pathway from G-Protein Families h_ndkDynaminPathway - Endocytotic role of NDK, Phosphins and Dynamin h_calcineurinPathway - Effects of calcineurin in Keratinocyte Differentiation h_nos1Pathway - Nitric Oxide Signaling Pathway h_vipPathway - Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells h_fcer1Pathway - Fc Epsilon Receptor I Signaling in Mast Cells h_hdacPathway - Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK) h_mef2dPathway - Role of MEF2D in T-cell Apoptosis h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart) h_tcrPathway - T Cell Receptor Signaling Pathway h_bcrPathway - BCR Signaling Pathway h_fMLPpathway - fMLP induced chemokine gene expression in HMC-1 cells h_pgc1aPathway - Regulation of PGC-1a h_ck1Pathway - Regulation of ck1/cdk5 by type 1 glutamate receptors
Reactome (by CSHL, EBI, and GO)
Protein Q08209 (Reactome details) participates in the following event(s):
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
