Human Gene NAA40 (uc009yoz.3)
  Description: Homo sapiens N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae) (NAA40), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr11:63,706,442-63,724,446 Size: 18,005 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr11:63,706,569-63,721,951 Size: 15,383 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:63,706,442-63,724,446)mRNA (may differ from genome)Protein (237 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NAA40_HUMAN
DESCRIPTION: RecName: Full=N-alpha-acetyltransferase 40; EC=2.3.1.-; AltName: Full=N-acetyltransferase 11; AltName: Full=NatD catalytic subunit;
FUNCTION: Responsible for the acetylation of the N-terminal residues of histones H4 and H2A.
SIMILARITY: Belongs to the acetyltransferase family. GNAT subfamily.
SIMILARITY: Contains 1 N-acetyltransferase domain.
SEQUENCE CAUTION: Sequence=CAI46006.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 24.26 RPKM in Pituitary
Total median expression: 383.60 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -50.60127-0.398 Picture PostScript Text
3' UTR -977.942495-0.392 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016181 - Acyl_CoA_acyltransferase
IPR000182 - GNAT_dom

Pfam Domains:
PF00583 - Acetyltransferase (GNAT) family

SCOP Domains:
55729 - Acyl-CoA N-acyltransferases (Nat)

ModBase Predicted Comparative 3D Structure on Q86UY6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0010485 H4 histone acetyltransferase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0043998 H2A histone acetyltransferase activity
GO:1990189 peptide-serine-N-acetyltransferase activity

Biological Process:
GO:0006474 N-terminal protein amino acid acetylation
GO:0006629 lipid metabolic process
GO:0043967 histone H4 acetylation
GO:0043968 histone H2A acetylation

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  BX647309 - Homo sapiens mRNA; cDNA DKFZp686G0693 (from clone DKFZp686G0693).
AK303557 - Homo sapiens cDNA FLJ57468 complete cds.
AK300451 - Homo sapiens cDNA FLJ57593 complete cds.
AK023910 - Homo sapiens cDNA FLJ13848 fis, clone THYRO1000855.
JF263566 - Homo sapiens N-alpha acetyl transferase 40 (NAA40) mRNA, complete cds.
JD226866 - Sequence 207890 from Patent EP1572962.
JD272546 - Sequence 253570 from Patent EP1572962.
BC041617 - Homo sapiens N-acetyltransferase 11 (GCN5-related, putative), mRNA (cDNA clone MGC:52164 IMAGE:5921480), complete cds.
BC052298 - Homo sapiens N-acetyltransferase 11 (GCN5-related, putative), mRNA (cDNA clone MGC:59726 IMAGE:6292760), complete cds.
JD473318 - Sequence 454342 from Patent EP1572962.
AK299041 - Homo sapiens cDNA FLJ58929 complete cds.
CU690900 - Synthetic construct Homo sapiens gateway clone IMAGE:100022440 5' read NAT11 mRNA.
HQ447708 - Synthetic construct Homo sapiens clone IMAGE:100071036; CCSB013676_01 N-acetyltransferase 11 (NAT11) gene, encodes complete protein.
KJ894740 - Synthetic construct Homo sapiens clone ccsbBroadEn_04134 NAA40 gene, encodes complete protein.
BC024160 - Homo sapiens N-acetyltransferase 11, mRNA (cDNA clone IMAGE:4080053).
JD354618 - Sequence 335642 from Patent EP1572962.
JD428033 - Sequence 409057 from Patent EP1572962.
JD204561 - Sequence 185585 from Patent EP1572962.
JD347264 - Sequence 328288 from Patent EP1572962.
JD514607 - Sequence 495631 from Patent EP1572962.
JD319070 - Sequence 300094 from Patent EP1572962.
JD167861 - Sequence 148885 from Patent EP1572962.
JD343103 - Sequence 324127 from Patent EP1572962.
JD111676 - Sequence 92700 from Patent EP1572962.
JD253851 - Sequence 234875 from Patent EP1572962.
JD126481 - Sequence 107505 from Patent EP1572962.
JD130612 - Sequence 111636 from Patent EP1572962.
JD183605 - Sequence 164629 from Patent EP1572962.
JD166558 - Sequence 147582 from Patent EP1572962.
JD117708 - Sequence 98732 from Patent EP1572962.
JD325801 - Sequence 306825 from Patent EP1572962.
JD471152 - Sequence 452176 from Patent EP1572962.
JD073699 - Sequence 54723 from Patent EP1572962.
JD207131 - Sequence 188155 from Patent EP1572962.
JD113544 - Sequence 94568 from Patent EP1572962.
JD183511 - Sequence 164535 from Patent EP1572962.
JD190127 - Sequence 171151 from Patent EP1572962.
JD190306 - Sequence 171330 from Patent EP1572962.
JD399428 - Sequence 380452 from Patent EP1572962.
JD143357 - Sequence 124381 from Patent EP1572962.
JD399747 - Sequence 380771 from Patent EP1572962.
JD205771 - Sequence 186795 from Patent EP1572962.
JD112630 - Sequence 93654 from Patent EP1572962.
JD131121 - Sequence 112145 from Patent EP1572962.
JD219331 - Sequence 200355 from Patent EP1572962.
JD415749 - Sequence 396773 from Patent EP1572962.
JD123176 - Sequence 104200 from Patent EP1572962.
JD189430 - Sequence 170454 from Patent EP1572962.
JD127134 - Sequence 108158 from Patent EP1572962.
JD210476 - Sequence 191500 from Patent EP1572962.
JD323897 - Sequence 304921 from Patent EP1572962.
JD383697 - Sequence 364721 from Patent EP1572962.
JD077048 - Sequence 58072 from Patent EP1572962.
JD339449 - Sequence 320473 from Patent EP1572962.
JD204392 - Sequence 185416 from Patent EP1572962.
JD448686 - Sequence 429710 from Patent EP1572962.
JD289676 - Sequence 270700 from Patent EP1572962.
JD428531 - Sequence 409555 from Patent EP1572962.
JD264550 - Sequence 245574 from Patent EP1572962.
JD055642 - Sequence 36666 from Patent EP1572962.
JD380364 - Sequence 361388 from Patent EP1572962.
JD207845 - Sequence 188869 from Patent EP1572962.
JD424544 - Sequence 405568 from Patent EP1572962.
JD413089 - Sequence 394113 from Patent EP1572962.
JD387653 - Sequence 368677 from Patent EP1572962.
JD071054 - Sequence 52078 from Patent EP1572962.
JD469403 - Sequence 450427 from Patent EP1572962.
JD313192 - Sequence 294216 from Patent EP1572962.
JD082826 - Sequence 63850 from Patent EP1572962.
JD493941 - Sequence 474965 from Patent EP1572962.
JD133078 - Sequence 114102 from Patent EP1572962.
JD465455 - Sequence 446479 from Patent EP1572962.
JD063088 - Sequence 44112 from Patent EP1572962.
JD144939 - Sequence 125963 from Patent EP1572962.
JD111595 - Sequence 92619 from Patent EP1572962.
JD080091 - Sequence 61115 from Patent EP1572962.
JD270029 - Sequence 251053 from Patent EP1572962.
JD246272 - Sequence 227296 from Patent EP1572962.
JD535780 - Sequence 516804 from Patent EP1572962.
JD473183 - Sequence 454207 from Patent EP1572962.
JD215689 - Sequence 196713 from Patent EP1572962.
JD288681 - Sequence 269705 from Patent EP1572962.
JD303625 - Sequence 284649 from Patent EP1572962.
JD111393 - Sequence 92417 from Patent EP1572962.
JD516691 - Sequence 497715 from Patent EP1572962.
JD422212 - Sequence 403236 from Patent EP1572962.
JD266861 - Sequence 247885 from Patent EP1572962.
JD230916 - Sequence 211940 from Patent EP1572962.
JD538375 - Sequence 519399 from Patent EP1572962.
JD140158 - Sequence 121182 from Patent EP1572962.
JD196141 - Sequence 177165 from Patent EP1572962.
JD058044 - Sequence 39068 from Patent EP1572962.
JD142588 - Sequence 123612 from Patent EP1572962.
JD100943 - Sequence 81967 from Patent EP1572962.
JD089546 - Sequence 70570 from Patent EP1572962.
JD222984 - Sequence 204008 from Patent EP1572962.
JD498017 - Sequence 479041 from Patent EP1572962.
JD376138 - Sequence 357162 from Patent EP1572962.
JD498016 - Sequence 479040 from Patent EP1572962.
JD142928 - Sequence 123952 from Patent EP1572962.
JD432520 - Sequence 413544 from Patent EP1572962.
JD294181 - Sequence 275205 from Patent EP1572962.
JD199520 - Sequence 180544 from Patent EP1572962.
JD421579 - Sequence 402603 from Patent EP1572962.
JD074958 - Sequence 55982 from Patent EP1572962.
JD453120 - Sequence 434144 from Patent EP1572962.
JD106086 - Sequence 87110 from Patent EP1572962.
JD426921 - Sequence 407945 from Patent EP1572962.
JD545646 - Sequence 526670 from Patent EP1572962.
JD486877 - Sequence 467901 from Patent EP1572962.
JD378638 - Sequence 359662 from Patent EP1572962.
JD341427 - Sequence 322451 from Patent EP1572962.
JD232075 - Sequence 213099 from Patent EP1572962.
JD490051 - Sequence 471075 from Patent EP1572962.
JD257046 - Sequence 238070 from Patent EP1572962.
JD294149 - Sequence 275173 from Patent EP1572962.
JD472452 - Sequence 453476 from Patent EP1572962.
JD472451 - Sequence 453475 from Patent EP1572962.
JD421527 - Sequence 402551 from Patent EP1572962.
JD179121 - Sequence 160145 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NAA40_HUMAN, NAT11, NM_024771, NP_079047, Q5HYL5, Q86UY6, Q9H897
UCSC ID: uc009yoz.3
RefSeq Accession: NM_024771
Protein: Q86UY6 (aka NAA40_HUMAN)
CCDS: CCDS8053.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_024771.2
exon count: 8CDS single in 3' UTR: no RNA size: 3352
ORF size: 714CDS single in intron: no Alignment % ID: 99.97
txCdsPredict score: 1476.00frame shift in genome: no % Coverage: 99.52
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.